Negri bodies

(pathology) Acidophil cytoplasmic inclusion bodies in neurons, considered diagnostic of rabies.

Intracytoplasmic inclusion bodies found in the brain and central nervous system cells of rabies victims.

An eosinophilic inclusion body found in the cytoplasm of certain nerve cells containing the rabies virus.

Micrograph with numerous rabies virions (small dark-grey rod-like particles) and Negri bodies, larger pathognomonic cellular inclusions of rabies infection.

Description: This micrograph depicts the histopathologic changes associated with rabies encephalitis prepared using an H&E stain. Note the Negri bodies, which are cellular inclusions found most frequently in the pyramidal cells of Ammon's horn, and the Purkinje cells of the cerebellum. They are also found in the cells of the medulla and various other ganglia.

Negri bodies are eosinophilic, sharply outlined, pathognomonic inclusion bodies (2–10 µm in diameter) found in the cytoplasm of certain nerve cells containing the virus of rabies, especially in Ammon's horn of the hippocampus. Often also found in the cerebellar cortex of postmortem brain samples of rabies victims.

They are named for Adelchi Negri.^[1]

References

1. ^ synd/2491 at Who Named It?

External links

• Negri+bodies at eMedicine Dictionary
• Slide at pathmicro.med.sc.edu - see bottom
• See pathology video of Negri bodies

v • d • e Eponymous medical signs for infectious disease Bacterial disease syphilis (Hutchinson's teeth, Hutchinson's triad, Abelin reaction, Westphal's sign) Viral disease measles (Koplik's spots) · yellow fever (Councilman body) · Tzanck test Inclusion bodies: poxvirus (Downie bodies/A, Guarnieri bodies/B) · rabies (Negri bodies) · Cowdry bodies Parasitic disease Chagas disease (Romana's sign) · African trypanosomiasis (Winterbottom's sign) · malaria (Schüffner's dots)

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