A nicotinic agonist is a drug which enhances the action at the nicotinic acetylcholine receptor (nAChR).
Examples include:
- nicotine (by definition -- the "nicotinic acetylcholine receptor" is named for its affinity for nicotine)
- acetylcholine, the endogenous agonist of nAChRs
- choline
- epibatidine
- lobeline
- varenicline
| Agonist | Receptor preference[1] | Mechanism[1] | Clinical use[1] |
|---|---|---|---|
| nicotine | stimulation | tobacco smoking cessation | |
| lobeline |
|
stimulation | |
| epibatidine | stimulation | none | |
| suxamethonium | Muscle type | depolarization block | muscle relaxant |
| decamethonium | Muscle type | depolarization block | none |
| varenicline | α4β2 | partial agonist | tobacco smoking cessation [2] |
References
- ^ a b c Unless else specified in table, then ref is: Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 149
- ^ nlm.nih.gov
See also
External links
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