n.pr
A diagnostic feature wherein apparently normal epithelium may be rubbed off with finger pressure.
Nikolsky's sign
| Dental Dictionary: Nikolsky’s sign |
n.pr
| 5min Related Video: Nikolsky's sign |
| Medical Dictionary: Ni·kol·sky's sign |
(nĭ-kŏl'skēz)
n.
n.
An indication of pemphigus vulgaris in which apparently normal epidermis may be separated at the basal layer and rubbed off when pressed with a sliding motion.
| Veterinary Dictionary: Nikolsky's sign |
In pemphigus vulgaris and some other bullous diseases, the outer epidermis separates easily from the basal layer on exertion of firm sliding manual pressure.
| Wikipedia: Nikolsky's sign |
[1] Nikolsky's sign is a clinical dermatological sign, named after Pyotr Nikolsky . Nikolsky's sign is positive when slight rubbing of the skin results in exfoliation of the skin's outermost layer.[2][3][4][5]
It is almost always present in toxic epidermal necrolysis,[6] A "positive" Nikolsky's sign is associated with pemphigus vulgaris. [7] Nikolsky's sign is useful in differentiating between pemphigus vulgaris (where it is present or positive) and bullous pemphigoid (where it is absent)
See also
References
- ^ Insert footnote text here
- ^ Moss C, Gupta E (September 1998). "The Nikolsky sign in staphylococcal scalded skin syndrome". Arch. Dis. Child. 79 (3): 290. PMID 9875032. PMC 1717681. http://adc.bmj.com/cgi/pmidlookup?view=long&pmid=9875032.
- ^ "eMedicine - Pemphigus Foliaceus : Article by Robert A Schwartz". http://www.emedicine.com/derm/topic318.htm.
- ^ Nikolski PV. Materiali K.uchenigu o pemphigus foliaceus [doctoral thesis]. Kiev. 1896.
- ^ "MedilinePlus: Nikolsky’s sign". http://www.nlm.nih.gov/medlineplus/ency/article/003285.htm.
- ^ PMID 17161178
- ^ Ma, O. Emergency Medicine Manual. McGraw Hill. 2004.
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