Nilutamide

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Drug Info:

Nilutamide

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Brand names: Nilandron™

Chemical formula:



Nilutamide Oral tablet

What is this medicine?

NILUTAMIDE (nye LOO ta mide) blocks the effect of the male hormone called testosterone. It is used with surgery to treat prostate cancer.
 
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
•liver disease
•lung disease
•an unusual or allergic reaction to nilutamide, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take with food or on an empty stomach. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What may interact with this medicine?

•alcohol
•phenytoin
•theophylline
•warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

This medicine may affect your vision. Your eyes may have trouble adjusting from light to dark. Be careful driving at night or through tunnels. Wearing tinted glasses may help.

Drinking alcohol with this medicine may cause facial flushing, low blood pressure, and tiredness. Avoid alcoholic drinks if you have such effects.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
•breathing problems
•dark urine
•general ill feeling or flu-like symptoms
•high blood pressure
•loss of appetite
•nausea, vomiting
•right upper belly pain
•trouble passing urine or change in the amount of urine
•unusually weak or tired
•yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•change in sex drive or performance
•changes in vision
•constipation
•dizziness
•dry skin
•hot flashes
•trouble sleeping

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Throw away any unused medicine after the expiration date.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

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Nilutamide
Systematic (IUPAC) name
5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]
imidazolidine-2,4-dione
Clinical data
Trade names Nilandron
AHFS/Drugs.com monograph
MedlinePlus a697044
Pregnancy cat.  ?
Legal status pr
Routes oral
Pharmacokinetic data
Half-life 38.0 to 59.1 hours
Identifiers
CAS number 63612-50-0 YesY
ATC code L02BB02
PubChem CID 4493
IUPHAR ligand 2864
DrugBank DB00665
ChemSpider 4337 YesY
UNII 51G6I8B902 YesY
KEGG D00965 YesY
ChEBI CHEBI:7573 YesY
ChEMBL CHEMBL1274 YesY
Chemical data
Formula C12H10F3N3O4 
Mol. mass 317.221 g/mol
SMILES eMolecules & PubChem
 YesY (what is this?)  (verify)

Nilutamide is an antiandrogen medication used in the treatment of advanced stage prostate cancer. Nilutamide blocks the androgen receptor, preventing its interaction with testosterone. Because most prostate cancer cells rely on the stimulation of the androgen receptor for growth and survival, nilutamide can prolong life in men with prostate cancer. Nilutamide is marketed under the name Nilandron in the United States and under the name Anandron in Canada.

References

  • Kassouf W, Tanguay S, Aprikian AG. Nilutamide as second line hormone therapy for prostate cancer after androgen ablation fails. J. Urol. 2003 May;169(5):1742-4. PMID 12686822
  • Moguilewsky M, Bertagna C, Hucher M. (1987) Pharmacological and clinical studies of the antiandrogen Anandron (nilutamide). J Steroid Biochem. (4-6):871-5.
  • Hsieh AC, Ryan CJ. (2008) Novel concepts in androgen receptor blockade. Cancer J. 14(1):11-14.




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