NIN
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NIN (gene)
| Ninein (GSK3B interacting protein) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | NIN; KIAA1565 | ||||||||||||
| External IDs | OMIM: 608684 MGI: 105108 HomoloGene: 40632 GeneCards: NIN Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 51199 | 18080 | |||||||||||
| Ensembl | ENSG00000100503 | ENSMUSG00000021068 | |||||||||||
| UniProt | Q8N4C6 | Q3UR16 | |||||||||||
| RefSeq (mRNA) | NM_016350.4 | NM_001081453 | |||||||||||
| RefSeq (protein) | NP_057434.4 | NP_001074922 | |||||||||||
| Location (UCSC) | Chr 14: 51.19 – 51.3 Mb |
Chr 12: 71.11 – 71.21 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Ninein is a protein that in humans is encoded by the NIN gene.[1][2][3] Ninein, together with its paralog Ninein-like protein is one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported.[3]
References
- ^ Hong YR, Chen CH, Chang JH, Wang S, Sy WD, Chou CK, Howng SL (Oct 2000). "Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta". Biochim Biophys Acta 1492 (2–3): 513–6. doi:10.1016/S0167-4781(00)00127-5. PMID 11004522.
- ^ Hong YR, Chen CH, Chuo MH, Liou SY, Howng SL (Feb 2001). "Genomic organization and molecular characterization of the human ninein gene". Biochem. Biophys. Res. Commun. 279 (3): 989–95. doi:10.1006/bbrc.2000.4050. PMID 11162463.
- ^ a b "Entrez Gene: NIN ninein (GSK3B interacting protein)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51199.
Further reading
- Nakajima D, Okazaki N, Yamakawa H et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Mack GJ, Rees J, Sandblom O et al. (1998). "Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome". Arthritis Rheum. 41 (3): 551–8. doi:10.1002/1529-0131(199803)41:3<551::AID-ART22>3.0.CO;2-X. PMID 9506584.
- Nagase T, Kikuno R, Nakayama M et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. PMID 10997877.
- Ou YY, Mack GJ, Zhang M, Rattner JB (2002). "CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation". J. Cell. Sci. 115 (Pt 9): 1825–35. PMID 11956314.
- Dammermann A, Merdes A (2002). "Assembly of centrosomal proteins and microtubule organization depends on PCM-1". J. Cell Biol. 159 (2): 255–66. doi:10.1083/jcb.200204023. PMC 2173044. PMID 12403812. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173044.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Chen CH, Howng SL, Cheng TS et al. (2003). "Molecular characterization of human ninein protein: two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle". Biochem. Biophys. Res. Commun. 308 (4): 975–83. doi:10.1016/S0006-291X(03)01510-9. PMID 12927815.
- Fritzler MJ, Zhang M, Stinton LM, Rattner JB (2004). "Spectrum of centrosome autoantibodies in childhood varicella and post-varicella acute cerebellar ataxia". BMC pediatrics 3: 11. doi:10.1186/1471-2431-3-11. PMC 222907. PMID 14503922. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=222907.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Innocenti M, Zucconi A, Disanza A et al. (2004). "Abi1 is essential for the formation and activation of a WAVE2 signalling complex". Nat. Cell Biol. 6 (4): 319–27. doi:10.1038/ncb1105. PMID 15048123.
- Vizmanos JL, Novo FJ, Román JP et al. (2004). "NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder". Cancer Res. 64 (8): 2673–6. doi:10.1158/0008-5472.CAN-04-0144. PMID 15087377.
- Howng SL, Hsu HC, Cheng TS et al. (2004). "A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors". FEBS Lett. 566 (1–3): 162–8. doi:10.1016/j.febslet.2004.04.024. PMID 15147888.
- Stillwell EE, Zhou J, Joshi HC (2006). "Human ninein is a centrosomal autoantigen recognized by CREST patient sera and plays a regulatory role in microtubule nucleation". Cell Cycle 3 (7): 923–30. PMID 15190203.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Delgehyr N, Sillibourne J, Bornens M (2005). "Microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function". J. Cell. Sci. 118 (Pt 8): 1565–75. doi:10.1242/jcs.02302. PMID 15784680.
- Cheng TS, Chang LK, Howng SL et al. (2006). "SUMO-1 modification of centrosomal protein hNinein promotes hNinein nuclear localization". Life Sci. 78 (10): 1114–20. doi:10.1016/j.lfs.2005.06.021. PMID 16154161.
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