Nisoldipine

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Nisoldipine

Systematic (IUPAC) name
isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Clinical data
Trade names	Sular
AHFS/Drugs.com	monograph
MedlinePlus	a696009
Pregnancy cat.	C (US)
Legal status	℞-only (US)
Routes	Oral
Pharmacokinetic data
Protein binding	99%
Half-life	7-12 hours
Identifiers
CAS number	63675-72-9^Y
ATC code	C08CA07
PubChem	CID 4499
IUPHAR ligand	2524
DrugBank	DB00401
ChemSpider	4343^N
UNII	4I8HAB65SZ^N
KEGG	D00618^Y
ChEMBL	CHEMBL1726^N
Chemical data
Formula	C₂₀H₂₄N₂O₆
Mol. mass	388.414 g/mol
N (what is this?) (verify)

Nisoldipine (INN) is a calcium channel blocker of the dihydropyridine class. It sold in the United States under the proprietary name Sular. Nisoldipine has tropism for cardiac blood vessels. ^[1]

External links

DDB 30009
Mielcarek J, Grobelny P, Szamburska O (2005). "The effect of beta-carotene on the photostability of nisoldipine.". Methods Find Exp Clin Pharmacol 27 (3): 167–71. doi:10.1358/mf.2005.27.3.890873. PMID 15834448.
Missan S, Zhabyeyev P, Dyachok O, Jones SE, McDonald TF (November 2003). "Block of cardiac delayed-rectifier and inward-rectifier K+ currents by nisoldipine". Br. J. Pharmacol. 140 (5): 863–70. doi:10.1038/sj.bjp.0705518. PMC 1574108. PMID 14530219. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1574108.
Hamilton S, Houle L, Thadani U (1999). "Rapid-release and coat-core formulations of nisoldipine in treatment of hypertension, angina, and heart failure.". Heart Dis 1 (5): 279–88. PMID 11720635.

References

^ http://www.sciencedirect.com/science/article/pii/S0002914999804469; Why is nisoldipine a specific agent in ischemic left ventricular dysfunction?

Channel blocker: calcium channel blockers (C08)

Selective

Dihydropyridines ("-dipine")	Amlodipine^# Aranidipine Azelnidipine Barnidipine Benidipine Cilnidipine Clevidipine Darodipine Efonidipine Felodipine Isradipine Lacidipine Manidipine Lercanidipine Mepirodipine Nicardipine Nifedipine^# Niludipin Nilvadipine Nimodipine Nisoldipine Nitrendipine Oxodipine Pranidipine Ryodipine

Phenylalkylamines ("-pamil")	Anipamil Devapamil Emopamil Falipamil Gallopamil Norverapamil Verapamil

1-4 Benzothiazepines ("-tiazem")	Clentiazem Diltiazem

Non-selective

Other/ungrouped

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

M: VAS

anat(a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot

noco/syva/cong/lyvd/tumr, sysi/epon, injr

proc, drug(C2s+n/3/4/5/7/8/9)

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