Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene.[1]
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.[2]
Interactions
Nitric oxide synthase 2A has been shown to interact with Caveolin 1[3] and Rac2.[4]
References
- ^ Geller DA, Lowenstein CJ, Shapiro RA, Nussler AK, Di Silvio M, Wang SC, Nakayama DK, Simmons RL, Snyder SH, Billiar TR (May 1993). "Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes". Proc Natl Acad Sci U S A 90 (8): 3491–5. PMID 7682706.
- ^ "Entrez Gene: NOS2A nitric oxide synthase 2A (inducible, hepatocytes)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4843.
- ^ Felley-Bosco, E; Bender F C, Courjault-Gautier F, Bron C, Quest A F (Dec. 2000). "Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (26): 14334–9. doi:10.1073/pnas.250406797. ISSN 0027-8424. PMID 11114180.
- ^ Kuncewicz, T; Balakrishnan P, Snuggs M B, Kone B C (Aug. 2001). "Specific association of nitric oxide synthase-2 with Rac isoforms in activated murine macrophages". Am. J. Physiol. Renal Physiol. (United States) 281 (2): F326-36. ISSN 0363-6127. PMID 11457725.
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1nsi: HUMAN INDUCIBLE NITRIC OXIDE SYNTHASE, ZN-BOUND, L-ARG COMPLEX
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2nsi: HUMAN INDUCIBLE NITRIC OXIDE SYNTHASE, ZN-FREE, SEITU COMPLEX
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4nos: HUMAN INDUCIBLE NITRIC OXIDE SYNTHASE WITH INHIBITOR
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