Nitrosourea

Nitrosourea
IUPAC name Nitrosourea
Identifiers
CAS number	13010-20-3 N
PubChem	105035
ChemSpider	94772 Y
Jmol-3D images	Image 1 Image 2
SMILES NC(=O)N=NO C(=O)(N)NN=O
InChI InChI=1S/CH3N3O2/c2-1(5)3-4-6/h(H3,2,3,5,6) Y Key: OSTGTTZJOCZWJG-UHFFFAOYSA-N Y
Properties
Molecular formula	CH3N3O2
Molar mass	89.05 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Urea

Streptozotocin

ENU

Nitrosourea is both the name of a molecule, and a class of compounds that include a nitroso (R-NO) group and a urea.

Examples

Examples include:

• Carmustine
• Lomustine
• Semustine
• Ethylnitrosourea (ENU)
• Streptozotocin

Nitrosourea compounds are DNA alkylating agents and are often used in chemotherapy.^[1] They are lipophilic and thus can cross the blood–brain barrier, making them useful in the treatment of brain tumors such as glioblastoma multiforme.^[2]

Side effects

Some nitrosoureas (e.g. lomustine) have been associated with the development of interstitial lung disease.^[3]

References

External links

• MeSH Nitrosourea+Compounds
• DDB 9052

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