Nizatidine

trade name: Axid; drug class: H₂-histamine receptor antagonist; action: inhibits histamine at H₂-receptor site in parietal cells, which inhibits gastric acid secretion; uses: duodenal ulcer, Zollinger-Ellison syndrome, gastric ulcers, hypersecretory conditions, gastroesophageal reflux disease, stress ulcers.

Brand names: Axid®Axid® AR

Chemical formula:

Drug Forms:
• Nizatidine Oral capsule (below)
• Nizatidine capsules
• Nizatidine Oral solution
• Nizatidine oral solution
• Nizatidine Oral tablet

Español:
• Nizatidina, Cápsula oral
• Cápsulas de nizatidina
• Nizatidina, Solución oral
• Nizatidina, Tableta oral

Nizatidine Oral capsule

What is this medicine?

NIZATIDINE (ni ZA ti deen) is a type of antihistamine that blocks the release of stomach acid. It is used to treat stomach or intestinal ulcers. It can relieve ulcer pain and discomfort, and the heartburn from acid reflux.
 
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
•blood in your stools (black or tarry stools) or if you have blood in your vomit
•kidney or liver disease
•pain or difficulty swallowing
•an unusual or allergic reaction to nizatidine, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding

How should I use this medicine?

Take this medicine by mouth. Follow the directions on the prescription label. Swallow the capsules with a drink of water. If you only take this medicine once a day take it at bedtime. Take your doses at regular intervals. Do not take your medicine more often than directed. Finish the full course of tablets prescribed by your doctor or health care professional even if you feel better.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What may interact with this medicine?

•aspirin and aspirin-like medicines
•delavirdine
•itraconazole
•ketoconazole

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Tell your doctor or health care professional if your ulcer pain does not start to get better or gets worse. You may need to take this medicine for several days before your symptoms get better.

Do not take with aspirin, ibuprofen, or other antiinflammatory medicines unless directed to do so by your health care professional. These can make your condition worse.

Do not smoke cigarettes or drink alcohol. These increase irritation in your stomach and can increase the time it will take for your ulcer to heal.

If you get black, tarry stools or vomit up what looks like coffee grounds, call your doctor or health care professional right away. You may have a bleeding ulcer.

If you need to take an antacid you should take it at least 1 hour before or 1 hour after this medicine. This medicine will not work as well if taken at the same time as an antacid.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
•breast swelling and tenderness
•confusion or hallucinations
•dark urine
•irritated, nervous
•yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•change in sex drive or performance
•constipation
•diarrhea
•dizziness
•headache

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

A histamine antagonist used in the treatment of active duodenal ulcers.

A histamine H₂-receptor antagonist, similar to cimetidine, used to reduce gastric acidity in the treatment of gastrointestinal ulceration.

Nizatidine

Systematic (IUPAC) name
N-(2-[(2-[(dimethylamino)methyl]thiazol-4-yl)methylthio]ethyl)-N-methyl-2-nitroethene-1,1-diamine
Identifiers
CAS number	76963-41-2
ATC code	A02BA04
PubChem	3033637
DrugBank	APRD00706
Chemical data
Formula	C12H21N5O2S2
Mol. mass	331.46 g/mol
Pharmacokinetic data
Bioavailability	>70%
Protein binding	35%
Metabolism	Hepatic
Half life	1-2 hours
Excretion	Renal
Therapeutic considerations
Licence data	US FDA:link
Pregnancy cat.	B3(AU)
Legal status	Prescription Only (S4)(AU) POM(UK) OTC(US)
Routes	Oral
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Nizatidine is a histamine H₂-receptor antagonist that inhibits stomach acid production, and commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). It was developed by Eli Lilly and is marketed under the trade names Tazac and Axid.

Contents 1 Clinical use 2 History and development 3 References 4 External links

Clinical use

Main article: H2-receptor antagonist

Certain preparations of nizatadine are now available over the counter in various countries including the United States. Nizatadine has been used experimentally to control weight gain associated with some antipsychotic medication. ^[1]

History and development

Nizatidine was developed by Eli Lilly, and was first marketed in 1987. It is considered to be equipotent with ranitidine and differs by the substitution of a thiazole-ring in place of the furan-ring in ranitidine. In September 2000 Eli Lilly announced that they will sell the sales and marketing rights for Axid, to Reliant Pharmaceuticals. ^[2] Subsequently, Reliant developed the oral solution of Axid and got approval by the U.S. Food and Drug Administration (FDA) in May 2004 and started marketing it. ^[3] However, a year later they sold rights of the Axid Oral Solution (including the issued patent US6,930,119 protecting the product) to Braintree Laboratories.^[4]

Nizatidine proved to be the last new histamine H₂-receptor antagonists introduced prior to the advent of proton pump inhibitors.

References

1. ^ Atmaca M, Kuloglu M, Tezcan E, Ustundag B, Kilic N (January 2004). "Nizatidine for the treatment of patients with quetiapine-induced weight gain". Hum Psychopharmacol 19 (1): 37–40. doi:10.1002/hup.477. PMID 14716710. 
2. ^ Eli Lilly and Company and Reliant Pharmaceuticals Announce
3. ^ Reliant Pharmaceuticals : Press Releases
4. ^ Reliant Pharmaceuticals : Press Releases

External links

• http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=2929
• Axid @ FDA
• Axid Oral Solution

v • d • e Histaminergics Receptor Ligands H1 Agonists: 2-Pyridylethylamine • Betahistine • Histamine • HTMT • UR-AK49 Antagonists: 1st Generation: Alimemazine • Azatadine • Bamipine • Bepotastine • Bromazine • Brompheniramine • Buclizine • Carbinoxamine • Chlorcyclizine • Chloropyramine • Chlorothen • Chlorpheniramine • Chlorphenoxamine • Cinnarizine • Clemastine • Clobenzepam • Clocinizine • Cyclizine • Cyproheptadine • Dacemazine • Deptropine • Dexbrompheniramine • Dexchlorpheniramine • Dimetindene • Diphenhydramine • Diphenylpyraline • Doxylamine • Embramine • Etymemazine • Histapyrrodine • Hydroxyethylpromethazine • Hydroxyzine • Iproheptine • Isopromethazine • Isothipendyl • Meclizine • Mepyramine • Mequitazine • Methafurylene • Methapyrilene • Methdilazine • Moxastine • Niaprazine • Orphenadrine • Oxatomide • Oxomemazine • p-Methyldiphenhydramine • Pheniramine • Phenyltoloxamine • Promethazine • Pyrilamine • Pyrrobutamine • Setastine • Talastine • Thenalidine • Thenyldiamine • Thiazinamium • Thonzylamine • Tolpropamine • Tripelennamine • Triprolidine; 2nd Generation: Acrivastine • Antazoline • Astemizole • Azatadine • Azelastine • Bamipine • Cetirizine • Clemizole • Clobenztropine • Deptropine • Dimebon • Ebastine • Emedastine • Epinastine • Ketotifen • Levocabastine • Loratadine • Mebhydrolin • Mizolastine • Olopatadine • Phenindamine • Pimethixene • Pyrrobutamine • Rupatadine • Terfenadine • Thenalidine • Tritoqualine; 3rd Generation: Desloratadine • Fexofenadine • Levocetirizine; Miscellaneous: Tricyclic Antidepressants (Amitriptyline, Doxepin, Trimipramine, etc) • Tetracyclic Antidepressants (Mianserin, Mirtazapine, etc) • Serotonin Antagonists and Reuptake Inhibitors (Trazodone, Nefazodone) • Typical Antipsychotics (Chlorpromazine, Thioridazine, etc) • Atypical Antipsychotics (Clozapine, Olanzapine, Quetiapine, etc) H2 Agonists: Amthamine • Betazole • Dimaprit • Histamine • HTMT • Impromidine • UR-AK49 Antagonists: Cimetidine • Famotidine • Lafutidine • Metiamide • Niperotidine • Nizatidine • Ranitidine • Roxatidine H3 Agonists: α-Methylhistamine • Cipralisant • Histamine • Imetit • Immepip • Immethridine • Methimepip • Proxyfan Antagonists: A-349,821 • A-423,579 • ABT-239 • Betahistine • Burimamide • Ciproxifan • Clobenpropit • Conessine • GSK-189,254 • Impentamine • Iodophenpropit • JNJ-5,207,852 • MK-0249 • NNC-38-1,049 • SCH-79,687 • Thioperamide • Tiprolisant • VUF-5,681 H4 Agonists: 4-Methylhistamine • Histamine • VUF-8,430 Antagonists: JNJ-7,777,120 • Thioperamide • VUF-6,002 Reuptake Inhibitors Plasmalemmal ..... Vesicular VMAT Inhibitors Ibogaine • Reserpine • Tetrabenazine Enzyme Inhibitors Anabolism HDC Inhibitors α-FMH • Brocresine • Catechin • Cyanidanol-3 • McN-A-1293 • ME • Meciadanol • Naringenin • Thiazol-4-yimethoxyamine • Tritoqualine • Zy-15,029 Catabolism HNMT Inhibitors Amodiaquine • BW-301U • Diphenhydramine • Harmaline • Metoprine • Quinacrine • SKF-91,488 • Tacrine DAO Inhibitors 1,4-Diamino-2-butyne • Aminoguanidine Others Precursors L-Histidine Cofactors Vitamin B6 (Pyridoxine, Pyridoxamine, Pyridoxal → Pyridoxal Phosphate)

v • d • e Drugs for acid related disorders: Drugs for peptic ulcer and GERD/GORD (A02B) H2 antagonists ("-idine") Cimetidine · Famotidine · Lafutidine · Niperotidine · Nizatidine · Ranitidine · Roxatidine Prostaglandins (E)/analogues ("-prost-") Misoprostol · Enprostil Proton-pump inhibitors ("-prazole") Dexlansoprazole · Esomeprazole · Lansoprazole · Omeprazole · Pantoprazole · Rabeprazole · Tenatoprazole Other Acetoxolone · Alginic acid · Carbenoxolone · Cetraxate · Gefarnate · Pirenzepine · Proglumide · Sucralfate · Sulglicotide · Teprenone · Troxipide · Zolimidine

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