| Nodal | |
|---|---|
| Genetic data | |
| Locus: | Chr. 10 q22.1 |
| Gene code: | HUGO code:NODAL |
| Protein Structure/Function | |
| Protein type: | cytokine |
| Functions: | cell differentiation |
| Domains: | TGFβ domain |
| Other | |
| Taxa expressing: | Homo sapiens; homologs: many metazoan phyla |
| Cell types: | many |
| Subcellular localization: | Extracellular |
| Medical/Biotechnological data | |
| Diseases: | Situs Ambiguus Mendelian Inheritance in Man (OMIM) 601265 |
| Database Links | |
| Entrez: | 4838 |
| OMIM: | 601265 |
| RefSeq: | NM_018055 |
| UniProt: | Q96S42 |
Nodal is a polypeptide member of the transforming growth factor beta superfamily of polypeptides. Like many other members of this superfamily, it is involved in cell differentiation. Nodal plays an essential role in mesoderm formation and axis specification. Nodal null mice die shortly after gastrulation[1].
References
- ^ Reissmann E,; Jornvall H, Blokzijl A, Andersson O, Chang C, Minchiotti G, Persico MG, Ibanez CF, Brivanlou AH. (Aug 2001). "The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development". Genes Dev. 15 (15). Entrez PubMed 11485994. Retrieved on 2006-07-05.
It is also a for of odaling, but through your nose
External links
| TGF beta signaling pathway | |
|---|---|
| TGF beta superfamily of ligands | TGF beta family
(TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal) |
| TGF beta receptors | TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2 TGFBR3: betaglycan |
| Transducers/SMAD | R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4 |
| Ligand Inhibitors | Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1 |
| Coreceptors | BAMBI - Cripto |
| Other | SARA |
Its also a form of yodaling, but through your nose!!!
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