Normoblast
McGraw-Hill Science & Technology Dictionary:
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normoblast
(′nör·mə′blast)
(histology) The smallest of the nucleated precursors of the erythrocyte; slightly larger than a mature adult erythrocyte. Also known as acidophilic erythroblast; arthochromatic erythroblast; eosinophilic erythroblast; karyocyte; metakaryocyte; metanitricyte; metarubricyte.
Oxford Dictionary of Biochemistry:
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normoblast
a normal precursor cell to an erythrocyte, characterized by condensation of the nucleus into a homogeneous densely staining body. Normoblasts are normally found only in hemopoietic tissue.
—normoblastic adj.
| normo+, normetanephrine, normetadrenaline | |
| normocyte, normoglycemia, normotensive |
Saunders Veterinary Dictionary:
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normoblast
A nucleated precursor cell in the erythrocytic series; metarubricyte.
Four developmental stages are recognized: the pronormoblast (prorubricyte); the basophilic normoblast (basophilic rubricyte, erythroblast), in which the cytoplasm is basophilic, the nucleus is large with clumped chromatin, and the nucleoli have disappeared; the polychromatic normoblast (polychromatic erythroblast, rubricyte), in which the nuclear chromatin shows increased clumping and the cytoplasm begins to acquire hemoglobin and takes on an acidophilic tint; and the orthochromatic normoblast (acidophilic normoblast, metarubricyte, orthochromatic erythroblast), the final stage before nuclear loss, in which the nucleus is small and ultimately becomes a blue-black homogeneous structureless mass.
Mosby's Dental Dictionary:
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normoblast
(nôr′mōblast)
n
n
A nucleated red blood cell found in the peripheral bloodstream in severe pernicious anemia and in some leukemias.
Wikipedia on Answers.com:
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Normoblast
An erythroblast is a type of red blood cell which still retains a cell nucleus. It is the immediate precursor of a normal erythrocyte.
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Contents
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Nomenclature
The term normoblast is sometimes used as a synonym for erythroblast, but at other times it is considered a subcategory. In the latter context, there are two types of erythroblasts:
- "normoblasts" - develop as expected
- "megaloblasts" - unusually large erythroblasts that can be associated with pernicious anemia and folic acid deficiency (collectively called megaloblastic anemia)
Development
There are four stages in the development of a normoblast.
| Illustration | Description | Image |
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Pronormoblast | |
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Basophilic normoblast |  |
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Polychromatic normoblast (also polychromatophilic) |  |
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Orthochromatic normoblast (also orthochromatophilic) |  |
Additional images
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Hematopoiesis
_diagram.png)
See also
External links
- MeSH Normoblasts
- Histology at BU 01804loa - "Bone Marrow and Hemopoiesis bone marrow smear, erythroblast series with proerythroblast "
- Histology at uiowa.edu
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McGraw-Hill Science & Technology Dictionary
McGraw-Hill Dictionary of Scientific and Technical Terms. Copyright © 2003, 1994, 1989, 1984, 1978, 1976, 1974 by McGraw-Hill Companies, Inc. All rights reserved.
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Oxford Dictionary of Biochemistry
Oxford University Press. Oxford Dictionary of Biochemistry and Molecular Biology © 1997, 2000, 2006 All rights reserved.
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Saunders Veterinary Dictionary
Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.
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Mosby's Dental Dictionary
Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved.
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