Normoblast

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(′nör·mə′blast)

(histology) The smallest of the nucleated precursors of the erythrocyte; slightly larger than a mature adult erythrocyte. Also known as acidophilic erythroblast; arthochromatic erythroblast; eosinophilic erythroblast; karyocyte; metakaryocyte; metanitricyte; metarubricyte.



a normal precursor cell to an erythrocyte, characterized by condensation of the nucleus into a homogeneous densely staining body. Normoblasts are normally found only in hemopoietic tissue.
normoblastic adj.

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A nucleated precursor cell in the erythrocytic series; metarubricyte.
Four developmental stages are recognized: the pronormoblast (prorubricyte); the basophilic normoblast (basophilic rubricyte, erythroblast), in which the cytoplasm is basophilic, the nucleus is large with clumped chromatin, and the nucleoli have disappeared; the polychromatic normoblast (polychromatic erythroblast, rubricyte), in which the nuclear chromatin shows increased clumping and the cytoplasm begins to acquire hemoglobin and takes on an acidophilic tint; and the orthochromatic normoblast (acidophilic normoblast, metarubricyte, orthochromatic erythroblast), the final stage before nuclear loss, in which the nucleus is small and ultimately becomes a blue-black homogeneous structureless mass.

(nôr′mōblast)
n

A nucleated red blood cell found in the peripheral bloodstream in severe pernicious anemia and in some leukemias.

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An erythroblast is a type of red blood cell which still retains a cell nucleus. It is the immediate precursor of a normal erythrocyte.

Contents

Nomenclature

The term normoblast is sometimes used as a synonym for erythroblast, but at other times it is considered a subcategory. In the latter context, there are two types of erythroblasts:

Development

There are four stages in the development of a normoblast.

HSC=Hematopoietic stem cell , Progenitor=Progenitor cell , L-blast=lymphoblast , Lymphocyte , Mo-blast=Monoblast , Monocyte , Myeloblast , Pro-M=Promyelocyte , Myelocyte , Meta-M=Metamyelocyte , Neutrophil , Eosinophil , Basophil , Pro-E=Proerythroblast , Baso-E=Basophilic erythroblast , poly-E=Polychromatic erythroblast , Ortho-E=orthochromatic erythroblast , Erythrocyte , Promegakaryocyte , megakaryocyte , Platlet
Illustration Description Image
Proerythroblast.png Pronormoblast
Basophilic erythroblast.png Basophilic normoblast Prorubricyte.jpg
Polychromatic erythroblast.png Polychromatic normoblast (also polychromatophilic) Rubricyte.jpg
Orthochromatic erythroblast.png Orthochromatic normoblast (also orthochromatophilic) Metarubricyte.jpg

Additional images

See also

External links


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