| Nitric oxide synthase 3 (endothelial cell) |
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| PDB rendering based on 1d0c. |
| Available structures |
| 1d0c, 1d0o, 1d1v, 1d1w, 1d1x, 1d1y, 1dm6, 1dm7, 1dm8, 1dmi, 1dmj, 1dmk, 1ed4, 1ed5, 1ed6, 1foi, 1foj, 1fol, 1foo, 1fop, 1i83, 1m9j, 1m9k, 1m9m, 1m9q, 1m9r, 1nse, 1p6l, 1p6m, 1p6n, 1q2o, 1rs8, 1rs9, 1zzs, 1zzt, 2g6o, 2hx2, 2nse, 3nos, 3nse, 4nse, 5nse, 6nse, 7nse, 8nse, 9nse |
| Identifiers |
| Symbols |
NOS3; ECNOS; NOS III; eNOS |
| External IDs |
OMIM: 163729 MGI: 97362 HomoloGene: 504 |
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| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
| Entrez |
4846 |
18127 |
| Ensembl |
ENSG00000164867 |
ENSMUSG00000028978 |
| UniProt |
P29474 |
Q7TSV7 |
| RefSeq |
NM_000603 (mRNA) |
NM_008713 (mRNA) |
| NP_000594 (protein) |
NP_032739 (protein) |
| Location |
Chr 7:
150.32 - 150.34 Mb |
Chr 5:
23.87 - 23.89 Mb |
| PubMed search |
[1] |
[2] |
Endothelial NOS (eNOS), also known as Nitric oxide synthase 3 (NOS3) or constitutive NOS (cNOS), is a nitric oxide synthase, but also denotes the human gene encoding it.
It generates NO in blood vessels and is involved with regulating vascular function. A constitutive Ca2+ dependent NOS provides a basal release of NO. eNOS is associated with plasma membranes surrounding cells and the membranes of Golgi bodies within cells.
Some association between a polymorphism in the gene and late-onset Alzheimer's disease in Chinese have been reported.[1]
Interactions
Endothelial NOS has been shown to interact with Caveolin 1,[2] Heat shock protein 90kDa alpha (cytosolic), member A1[3][4][5] and GUCY1B3.[3]
References
- ^ Binbin Wang, Sainan Tan, Ze Yang, Yan-Chen Xie, Jing Wang, Sirui Zhou, Shu Li, Chenguang Zheng and Xu Ma (February 2008). "Association Between Alzheimer’s Disease and the NOS3 gene Glu298Asp Polymorphism in Chinese". Journal of Molecular Neuroscience 34 (2).
- ^ García-Cardeña, G; Fan R, Stern D F, Liu J, Sessa W C (Nov. 1996). "Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1". J. Biol. Chem. (UNITED STATES) 271 (44): 27237–40. ISSN 0021-9258. PMID 8910295.
- ^ a b Venema, Richard C; Venema Virginia J, Ju Hong, Harris M Brennan, Snead Connie, Jilling Tamas, Dimitropoulou Christiana, Maragoudakis Michael E, Catravas John D (Aug. 2003). "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". Am. J. Physiol. Heart Circ. Physiol. (United States) 285 (2): H669-78. doi:10.1152/ajpheart.01025.2002. ISSN 0363-6135. PMID 12676772.
- ^ Harris, M B; Ju H, Venema V J, Blackstone M, Venema R C (Sep. 2000). "Role of heat shock protein 90 in bradykinin-stimulated endothelial nitric oxide release". Gen. Pharmacol. (England) 35 (3): 165–70. ISSN 0306-3623. PMID 11744239.
- ^ Stepp, David W; Ou Jingsong, Ackerman Allan W, Welak Scott, Klick David, Pritchard Kirkwood A (Aug. 2002). "Native LDL and minimally oxidized LDL differentially regulate superoxide anion in vascular endothelium in situ". Am. J. Physiol. Heart Circ. Physiol. (United States) 283 (2): H750-9. doi:10.1152/ajpheart.00029.2002. ISSN 0363-6135. PMID 12124224.
Further reading
- de la Monte SM, Lu BX, Sohn YK, et al. (2000). "Aberrant expression of nitric oxide synthase III in Alzheimer's disease: relevance to cerebral vasculopathy and neurodegeneration.". Neurobiol. Aging 21 (2): 309–19. doi:10.1016/S0197-4580(99)00108-6. PMID 10867216.
- Shaul PW (2002). "Regulation of endothelial nitric oxide synthase: location, location, location.". Annu. Rev. Physiol. 64: 749–74. doi:10.1146/annurev.physiol.64.081501.155952. PMID 11826287.
- Wu KK (2002). "Regulation of endothelial nitric oxide synthase activity and gene expression.". Ann. N. Y. Acad. Sci. 962: 122–30. PMID 12076969.
- Alp NJ, Channon KM (2005). "Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.". Arterioscler. Thromb. Vasc. Biol. 24 (3): 413–20. doi:10.1161/01.ATV.0000110785.96039.f6. PMID 14656731.
- Tai SC, Robb GB, Marsden PA (2005). "Endothelial nitric oxide synthase: a new paradigm for gene regulation in the injured blood vessel.". Arterioscler. Thromb. Vasc. Biol. 24 (3): 405–12. doi:10.1161/01.ATV.0000109171.50229.33. PMID 14656742.
- Kawashima S, Yokoyama M (2004). "Dysfunction of endothelial nitric oxide synthase and atherosclerosis.". Arterioscler. Thromb. Vasc. Biol. 24 (6): 998–1005. doi:10.1161/01.ATV.0000125114.88079.96. PMID 15001455.
- Duda DG, Fukumura D, Jain RK (2004). "Role of eNOS in neovascularization: NO for endothelial progenitor cells.". Trends in molecular medicine 10 (4): 143–5. doi:10.1016/j.molmed.2004.02.001. PMID 15162796.
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PDB Gallery |
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1d0c: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 3-BROMO-7-NITROINDAZOLE (H4B FREE)
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1d0o: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 3-BROMO-7-NITROINDAZOLE (H4B PRESENT)
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1d1v: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH S-ETHYL-N-PHENYL-ISOTHIOUREA (H4B BOUND)
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1d1w: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 2-AMINOTHIAZOLINE (H4B BOUND)
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1d1x: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1,4-PBITU (H4B BOUND)
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1d1y: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1,3-PBITU (H4B FREE)
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1dm6: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH N-(4-CHLOROPHENYL)-N'-HYDROXYGUANIDINE (H4B FREE)
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1dm7: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH HOMOARGININE (H4B FREE)
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1dm8: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1,2,4-TRIAZOLE-CARBOXAMIDINE (H4B BOUND)
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1dmi: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 6S-H4B
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1dmj: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 5,6-CYCLIC-TETRAHYDROPTERIDINE
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1dmk: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 4-AMINO-6-PHENYL-TETRAHYDROPTERIDINE
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1ed4: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH IPITU (H4B FREE)
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1ed5: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH NNA(H4B FREE)
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1ed6: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH L-NIO (H4B FREE)
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1foi: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1400W(H4B-FREE)
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1foj: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 7-NITROINDAZOLE-2-CARBOXAMIDINE (H4B PRESENT)
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1fol: REDUCED BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH L-ARG(H4B-FREE)
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1foo: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH L-ARG AND NO(H4B-FREE)
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1fop: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH L-ARG AND NO(H4B-BOUND)
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1i83: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH N1,N14-BIS((S-METHYL)ISOTHIOUREIDO)TETRADECANE (H4B FREE)
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1m9j: human endothelial nitric oxide synthase with chlorzoxazone bound
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1m9k: Human Endothelial Nitric Oxide Synthase with 7-Nitroindazole Bound
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1m9m: human endothelial nitric oxide synthase with 6-nitroindazole bound
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1m9q: human endothelial nitric oxide synthase with 5-nitroindazole bound
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1m9r: human endothelial nitric oxide synthase with 3-Bromo-7-Nitroindazole bound
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1nse: BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE
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1p6l: Bovine endothelial NOS heme domain with L-N(omega)-nitroarginine-2,4-L-diaminobutyric amide bound
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1p6m: Bovine endothelial NOS heme domain with (4S)-N-(4-amino-5-[aminoethyl]aminopentyl)-N'-nitroguanidine bound
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1p6n: Bovine endothelial NOS heme domain with L-N(omega)-nitroarginine-(4R)-amino-L-proline amide bound
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