NPR1

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
Identifiers
Symbols	NPR1; ANPRA; ANPa; GUC2A; GUCY2A; NPRA
External IDs	OMIM: 108960 MGI: 97371 HomoloGene: 37367 GeneCards: NPR1 Gene
EC number	4.6.1.2
Gene Ontology Molecular function • nucleotide binding • guanylate cyclase activity • protein kinase activity • receptor activity • ATP binding • GTP binding • peptide receptor activity, G-protein coupled • transferase activity, transferring phosphorus-containing groups • natriuretic peptide receptor activity • peptide hormone binding • protein kinase binding • hormone binding Cellular component • plasma membrane • integral to plasma membrane Biological process • cGMP biosynthetic process • cell surface receptor linked signaling pathway • receptor guanylyl cyclase signaling pathway • body fluid secretion • regulation of blood pressure • negative regulation of angiogenesis • negative regulation of cell growth • positive regulation of cGMP biosynthetic process • intracellular signal transduction • positive regulation of urine volume • positive regulation of renal sodium excretion • regulation of vasodilation • dopamine metabolic process • regulation of vascular permeability • negative regulation of smooth muscle cell proliferation • regulation of blood vessel size Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4881	18160
Ensembl	ENSG00000169418	ENSMUSG00000027931
UniProt	P16066	Q2TAY4
RefSeq (mRNA)	NM_000906	NM_008727.5
RefSeq (protein)	NP_000897	NP_032753.5
Location (UCSC)	Chr 1: 153.65 – 153.67 Mb	Chr 3: 90.25 – 90.27 Mb
PubMed search	[1]	[2]

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene.

Function

NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP and BNP, respectively).^[1]

It is localized in the kidney^[2] where it results in natriuresis upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and adipocytes.^[2]

References

Further reading

See also

• Atrial natriuretic peptide receptor

External links

• MeSH NPR1+protein,+human

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.