NS-2359
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NS-2359
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| Systematic (IUPAC) name | |
| (1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(methoxymethyl)-8-azabicyclo[3.2.1]octane | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| ATC code | None |
| PubChem | CID 11408320 |
| Chemical data | |
| Formula | C15H19Cl2NO |
| Mol. mass | 300.223 g/mol |
| SMILES | eMolecules & PubChem |
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NS-2359 (GSK-372,475) is a serotonin-norepinephrine-dopamine reuptake inhibitor. It was under development by GlaxoSmithKline (GSK) as an antidepressant,[1] but was discontinued in 2009 when phase II clinical trials turned up disappointing results and did not support further effort by the company.[1] NS-2359 was also in clinical trials for the treatment of ADHD,[2] phase II having been completed in 2007.[3] A trial exploring the effect of NS-2359 on cocaine-experienced individuals is currently ongoing.[4]
Another scientific article on NS-2359 was recently (2011) published.[5] As can be seen from reading the abstract to the citation, the compound failed to perform in clinical trials for the treatment of depression.
See also
References
- ^ a b "NeuroSearch announces the results of Phase II Proof of Concept studies with NS2359 in depression". https://newsclient.omxgroup.com/cdsPublic/viewDisclosure.action?disclosureId=313018&messageId=372903.
- ^ Wilens, T. E.; Klint, T.; Adler, L.; West, S.; Wesnes, K.; Graff, O.; Mikkelsen, B. (2008). "A randomized controlled trial of a novel mixed monoamine reuptake inhibitor in adults with ADHD". Behavioral and Brain Functions 4: 24. doi:10.1186/1744-9081-4-24. PMC 2442604. PMID 18554401. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2442604.
- ^ http://clinicaltrials.gov/ct2/show/NCT00467428
- ^ http://clinicaltrials.gov/ct2/show/NCT00032916
- ^ Learned, S.; Graff, O.; Roychowdhury, S.; Moate, R.; Krishnan, K. R.; Archer, G.; Modell, J. G.; Alexander, R. et al (2011). "Efficacy, safety, and tolerability of a triple reuptake inhibitor GSK372475 in the treatment of patients with major depressive disorder: Two randomized, placebo- and active-controlled clinical trials". Journal of Psychopharmacology. doi:10.1177/0269881111424931. PMID 22048884.
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