NYX may refer to:
- Nyx, in Greek mythology, Nyx was the primordial goddess of the night
- NYX (comics), an American comic book miniseries by Marvel Comics
- Nyx (Image Comics), a character of the Spawn (comics) comic book series.
- NYSE Euronext, (NYSE: NYX, Euronext: NYX) (formerly NYSE Group, Inc.) is a for-profit corporation that operates multiple securities exchanges, most notably the New York Stock Exchange (the "Big Board"), Euronext, and NYSE Arca (formerly known as ArcaEx).
- Nyx, a free public-access Internet Service Provider operational since the late 1980's.
- Nyx, an experimental prototype for the Amiga computer platform's AAA chipset, designed by Commodore engineer Dave Haynie in 1992 .
- Nyx, is a Gallente Mothership in the Massively Multiplayer Online Game, EVE Online
- NyxQuest: Kindred Spirits, A 2D-3D hybrid video game for WiiWare by Over the Top Studios.
NYX may also be:
- 3908 Nyx, is an Amor and Mars-crosser asteroid
- Nix (moon), a moon of Pluto
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