O-806
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| Systematic (IUPAC) name | |
| (6aR)-3-(6-bromohex-2-ynyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| ATC code | ? |
| PubChem | CID 10549140 |
| ChemSpider | 26001356  |
| Chemical data | |
| Formula | C22H27BrO2 |
| Mol. mass | 403.352 g/mol |
| SMILES | eMolecules & PubChem |
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O-806 is a drug which is a cannabinoid derivative that is used in scientific research. It is described as a mixed agonist/antagonist at the cannabinoid receptor CB1, meaning that it acts as an antagonist when co-administered alongside a more potent CB1 agonist, but exhibits weak partial agonist effects when administered by itself.[1][2]
References
- ^ Griffin, G.; Wray, E.; Rorrer, W.; Crocker, P.; Ryan, W.; Saha, B.; Razdan, R.; Martin, B. et al. (1999). "An investigation into the structural determinants of cannabinoid receptor ligand efficacy". British journal of pharmacology 126 (7): 1575–1584. doi:10.1038/sj.bjp.0702469. PMC 1565939. PMID 10323589.
- ^ Griffin, G.; Wray, E.; Martin, B.; Abood, M. (1999). "Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum". British journal of pharmacology 128 (3): 684–688. doi:10.1038/sj.bjp.0702806. PMC 1571656. PMID 10516649.
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