a concept formulated to explain the inherent differing reactivities, often expressed in an enzymic reaction, of identical chemical groups in a prochiral molecule. It states that there must be at least three points of attachment of a substrate molecule to the active site of an enzyme. It is similar to the Easson — Stedman model. [After Alexander GeorgeOgston (1911 — 96), British biophysicist who formulated it in 1948.]