Oligoastrocytoma

Oligoastrocytomas are a subset of brain tumor that present with an appearance of mixed glial cell origin, astrocytoma and oligodendroglioma.^[1] Often called a "mixed glioma", about 2.3% of all reported brain tumors are diagnosed as oligoastrocytoma. The median age of diagnosis is 42 years of age. Oligoastrocytomas, like astrocytomas and oligodendrogliomas, can be divided into low-grade and anaplastic variant, the latter characterized by high cellularity, conspicuous cytologic atypism, mitotic activity and, in some cases, microvascular proliferation and necrosis.

However, lower grades can have less aggressive biology.

These are largely supratentorial tumor of adulthood that favor the frontal and temporal lobes.

Symptoms

There are many possible symptoms of oligodendrogliomas that are similar to other gliomas. These symptoms may include headache, seizure and speech or motor changes.

Diagnosis

A Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) scan is necessary to characterize the anatomy of this tumor (size, location, heter/homogeneity). However, final diagnosis of this tumor, like most tumors, relies on histopathologic examination (biopsy examination).

Treatment

If resected, the surgeon will remove as much of this tumor as possible, without disturbing eloquent regions of the brain (speech/motor cortex) and other critical brain structure. Thereafter, treatment may include chemotherapy and radiation therapy of doses and types ranging based upon the patient's needs. Subsequent MRI examination are often necessary to monitor the resection cavity.

Prognosis

Even after surgery, an oligoastrocytoma will often recur. The treatment for a recurring brain tumor may include surgical resection, chemo and radiation therapy. Survival time of this brain tumor varies - younger age and low-grade initial diagnosis are factors in improved survival time.

References

External links

• Samantha Dickson Brain Tumour Trust: brain tumour research and support charity
• SDBTT Astro Fund: funding research and offering support to those affected by low-grade oligoastrocytomas
• Brain and Spinal Tumors: Hope Through Research (National Institute of Neurological Disorders and Stroke)
• Images

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