OPP or Opp may refer to:
- Ontario Provincial Police, the police force of Ontario, Canada
- Opp, Alabama, a town in southern Alabama, United States
- "O.P.P. (song)", a song by Naughty by Nature from the album Naughty by Nature
- Object Push Profile, a Bluetooth communications protocol based on the OBEX protocol
- On-Line Picasso Project, a summary of the life and work of Pablo Picasso
- Open Prosthetics Project, a project dedicated to creation of public domain prosthetics
- Orangi Pilot Project, a development project in slums of Karachi, Pakistan
- 2-Phenylphenol (or ortho-phenylphenol), an organic compound used as a fungicide
- Oink's Pink Palace, a bittorrent tracker
- Omega Psi Phi, one of the first black male fraternities
OPP could also be:
- Other person problems
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