oxygenase

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(ŏk'sĭ-jə-nās', -nāz') pronunciation
n.
An oxidoreductase that catalyzes the incorporation of molecular oxygen into its substrate.


(ŏk'sĭ-jə-nās', -nāz')
n.

An enzyme that catalyzes the incorporation of molecular oxygen into its substrate. Also called direct oxidase.


an enzyme that catalyses a reaction in which molecular oxygen is incorporated into an organic compound (the donor). Monooxygenases (EC class 1.13) act upon single donors, and dioxygenases (EC class 1.14) act upon paired donors.

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Any enzyme of the oxidoreductase class that catalyzes the incorporation of both atoms of molecular oxygen into the substrate.

An oxygenase is any enzyme that oxidizes a substrate by transferring the oxygen from molecular oxygen O2 (as in air) to it. The oxygenases form a class of oxidoreductases; their EC number is EC 1.13 or EC 1.14.

Oxygenases were discovered in 1955 simultaneously by two groups, Osamu Hayaishi from Japan[1][2][3] and Howard S. Mason from the US.[4][5]

There are two types of oxygenases:

Among the most important monooxygenases are the cytochrome P450 oxidases, responsible for breaking down numerous chemicals in the body.

References

  1. ^ Hayaishi et al. (1955) Mechanism of the pyrocatechase reaction, J. Am. Chem. Soc. 77 (1955) 5450-5451
  2. ^ Sligar SG, Makris TM, Denisov IG (2005). "Thirty years of microbial P450 monooxygenase research: peroxo-heme intermediates--the central bus station in heme oxygenase catalysis". Biochem. Biophys. Res. Commun. 338 (1): 346–54. doi:10.1016/j.bbrc.2005.08.094. PMID 16139790. 
  3. ^ Hayaishi O (2005). "An odyssey with oxygen". Biochem. Biophys. Res. Commun. 338 (1): 2–6. doi:10.1016/j.bbrc.2005.09.019. PMID 16185652. 
  4. ^ Mason HS, Fowlks WK, and Peterson E. (1955) Oxygen transfer and electron transport by the phenolase complex. J. Am. Chem. Soc.; 77(10) pp 2914 - 2915
  5. ^ Waterman MR (2005). "Professor Howard Mason and oxygen activation". Biochem. Biophys. Res. Commun. 338 (1): 7–11. doi:10.1016/j.bbrc.2005.08.120. PMID 16153596. 
  6. ^ Bugg TDH (2003). "Dioxygenase enzymes: catalytic mechanisms and chemical models". Tetrahedron 59 (36): 7075–7101. doi:10.1016/S0040-4020(03)00944-X. 

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