The study of ancient diseases and their origins. Paleopathology is especially important in the understanding of the origins, prevalence, and spread of infectious diseases, including how humans have contributed to the spread of disease and how they can overcome it. See also Epidemiology; Infectious disease; Pathology.
Hypothesis testing of populations has contributed to the field of paleopathology, as has application of macroscopic (visual) examination, routine x-ray, computerized tomography (CAT) scans, magnetic resonance imaging (MRI), electron microscopy, and immunologic, chemical, and mass spectrophotometry techniques to skeletons, soft tissue, and even scat (animal droppings). See also Computerized tomography; Magnetic resonance; X-ray diffraction.
The scientific method in paleopathology is based upon comparison of archeologic or paleontologic findings with individuals documented to have the disease. To this end the following basic tenets are observed: (1) Tissue must be adequately preserved to allow recognition of disease and distinguish possible pseudopathology or postdeath artifact. (2) The manifestations of a disease must be sufficiently stable across generations to allow comparison of ancient with modern disease. (3) Analysis of entire skeletons is more accurate than analysis of isolated bones. (4) Analysis of afflicted populations (paleoepidemiology) is more accurate than analysis of isolated skeletons.
The range of diagnostic methods used in paleopathology is extensive. Skeletal remains are visually examined to identify occurrence and nature of alterations, mapping their skeletal distribution. Internal structure can then be assessed, preferably by a nondestructive technique. Even fossils are not simply casts of external surfaces, but have a visualizable internal structure.
Mummies provide an additional source of information. Rehydration of mummy tissue allows standard soft tissue histology, providing information often transcending that available through study of bones. Anthropologic study of artifacts such as daggers that sometimes accompany mummies and skeletons has also contributed to the understanding of ancient lifestyles and the diseases which impacted them. See also Histology.
Some of the diseases recognized in living individuals for which evidence has also been found in ancient life forms include tuberculosis, leprosy, arthritis, cancer, and various parasitic diseases. See also Arthritis; Cancer (medicine); Leprosy; Parasitology; Tuberculosis.




