Palifermin
Drug Info:
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Palifermin
Brand names: Kepivance™
- Drug Forms:
- Palifermin Solution for injection (below)
- Palifermin injection
- Espa�ol:
- Palifermin Solución para inyección
Palifermin Solution for injection
What is this medicine?
PALIFERMIN (pal ee FER min) is a man-made form of a natural growth factor. It is used to treat and to prevent severe mouth sores in patients with blood-related cancers receiving chemotherapy and/or radiation therapy.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
•an unusual or allergic reaction to palifermin, E. coli protein, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding
How should I use this medicine?
This medicine is for injection into a vein. It is given by a health care professional in a hospital or clinic setting.
Talk to your pediatrician regarding the use of this medicine in children. This medicine is not approved for use in children.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
Missing a dose is probably not harmful. If you miss a dose, simply resume taking it on your previous schedule. Do not take double or extra doses.What may interact with this medicine?
•medicines to treat cancer
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Visit your doctor or health care professional for regular checks on your progress.
Do not use this medicine if you have a cancer that is not a blood-related cancer. This medicine may cause other cancers to grow.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
•burning, tingling in or around the mouth
•fever
•high blood pressure
•joint pain
•swelling of the hands or feet
•thickening of the tongue
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•change in tongue color
•changes in taste
•stomach upset
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
This drug is given in a hospital or clinic and will not be stored at home.
Last updated: 12/16/2004 9:12:00 AM
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
Oxford A-Z of Medicinal Drugs:
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palifermin
A drug used to treat mouth sores and ulcers in people with leukaemia or lymphoma (see cancer) who are receiving high-dose chemo- and radiotherapy. It is available as a form for injection on prescription only.
Side effects:
include altered taste, thickening and discoloration of the tongue, fluid retention, rash, and itching.
Precautions:
palifermin is not recommended for pregnant or breastfeeding women.
Proprietary preparation:
Kepivance.
| paint, paclitaxel, Pyralvex | |
| paliperidone, palivizumab, palonosetron |
Wikipedia on Answers.com:
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Palifermin
| Clinical data | |
|---|---|
| AHFS/Drugs.com | monograph |
| MedlinePlus | a605017 |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 162394-19-6  |
| ATC code | V03AF08 |
| DrugBank | DB00039 |
| UNII | QMS40680K6 |
| ChEMBL | CHEMBL1201821  |
| Chemical data | |
| Formula | C721H1142N202O204S9 |
| Mol. mass | 16192.7 g/mol |
 (what is this?) (verify) |
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Palifermin (trade name Kepivance, marketed by Biovitrum) is a human recombinant keratinocyte growth factor (KGF)[1] produced in Escherichia coli. KGF stimulates the growth of cells that line the surface of the mouth and intestinal tract.[2]
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Contents
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Uses
When patients with blood cancers (leukemia and lymphoma) receive high dose chemotherapy and radiation therapy to undergo bone marrow transplantation, they usually get severe oral mucositis.[3] Palifermin binds to epithelial cell-surface receptors and stimulates epithelial cell proliferation, differentiation, and upregulation of cytoprotective mechanisms. It reduces the incidence and duration of severe oral mucitis[4][5] by protecting those cells and stimulating the growth of new epithelial cells to build up the mucosal barrier.
Palifermin is also being studied in the prevention and treatment of oral mucositis and dysphagia (difficulty swallowing) in other types of cancer.[2]
Costs
Palifermin costs approximately 5,000 Euros per treatment for a 70 kg patient.[6]
References
- ^ Beaven AW, Shea TC (September 2007). "The effect of palifermin on chemotherapyand radiation therapy-induced mucositis: a review of the current literature". Support Cancer Ther 4 (4): 188–97. doi:10.3816/SCT.2007.n.014. PMID 18632516. http://cigjournals.metapress.com/openurl.asp?genre=article&id=doi:10.3816/SCT.2007.n.014.
- ^ a b Kepivance entry in the public domain NCI Dictionary of Cancer Terms
- ^ Blijlevens N, Sonis S (May 2007). "Palifermin (recombinant keratinocyte growth factor-1): a pleiotropic growth factor with multiple biological activities in preventing chemotherapy- and radiotherapy-induced mucositis". Ann. Oncol. 18 (5): 817–26. doi:10.1093/annonc/mdl332. PMID 17030544. http://annonc.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17030544.
- ^ Spielberger R, Stiff P, Bensinger W, et al. (December 2004). "Palifermin for oral mucositis after intensive therapy for hematologic cancers". N. Engl. J. Med. 351 (25): 2590–8. doi:10.1056/NEJMoa040125. PMID 15602019. http://content.nejm.org/cgi/pmidlookup?view=short&pmid=15602019&promo=ONFLNS19.
- ^ McDonnell AM, Lenz KL (January 2007). "Palifermin: role in the prevention of chemotherapy- and radiation-induced mucositis". Ann Pharmacother 41 (1): 86–94. doi:10.1345/aph.1G473. PMID 17190850. http://www.theannals.com/cgi/pmidlookup?view=long&pmid=17190850.
- ^ NEW DRUGS in TRANSPLANTATION, EBMT Meeting, France, March 2007 C. PAILLET, Pharmacist, Pharm D. C. RENZULLO, Pharmacist, Pharm D. Edouard Herriot Hospital, Lyon, FRANCE
External links
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This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".
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Oxford A-Z of Medicinal Drugs
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