Pancreatic polypeptide receptor 1
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Pancreatic polypeptide receptor 1
| Pancreatic polypeptide receptor 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | PPYR1; MGC116897; NPY4-R; NPY4R; PP1; Y4 | ||||||||||||
| External IDs | OMIM: 601790 MGI: 105374 HomoloGene: 38119 IUPHAR: Y4 GeneCards: PPYR1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5540 | 19065 | |||||||||||
| Ensembl | ENSG00000204174 | ENSMUSG00000048337 | |||||||||||
| UniProt | P50391 | Q3UN46 | |||||||||||
| RefSeq (mRNA) | XM_001129329 | NM_008919.4 | |||||||||||
| RefSeq (protein) | XP_001129329 | NP_032945.3 | |||||||||||
| Location (UCSC) | Chr 10: 47.08 – 47.09 Mb |
Chr 14: 34.96 – 34.97 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Neuropeptide Y receptor type 4 is a protein that in humans is encoded by the PPYR1 gene.[1][2]
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Contents
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Selective Ligands
Agonists
- Pancreatic polypeptide
- Neuropeptide Y (endogenous agonist, non subtype selective)
- Peptide YY
- GR-231,118 (mixed NPY1 antagonist / NPY4 agonist, CAS# 158859-98-4)
Antagonists
See also
References
- ^ Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (Feb 1998). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics 46 (2): 287–90. doi:10.1006/geno.1997.5024. PMID 9417917.
- ^ "Entrez Gene: PPYR1 pancreatic polypeptide receptor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5540.
- ^ Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A (2007). "Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence". Journal of Receptor and Signal Transduction Research 27 (4): 217–33. doi:10.1080/10799890701505206. PMID 17885919.
External links
- "Neuropeptide Y Receptors: Y4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2370.
Further reading
- Keire DA, Bowers CW, Solomon TE, Reeve JR (2002). "Structure and receptor binding of PYY analogs.". Peptides 23 (2): 305–21. doi:10.1016/S0196-9781(01)00602-7. PMID 11825645.
- Balasubramaniam A (2002). "Clinical potentials of neuropeptide Y family of hormones.". Am. J. Surg. 183 (4): 430–4. doi:10.1016/S0002-9610(02)00803-6. PMID 11975932.
- Parker E, Van Heek M, Stamford A (2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.". Eur. J. Pharmacol. 440 (2-3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.
- Benaim G, Villalobo A (2002). "Phosphorylation of calmodulin. Functional implications.". Eur. J. Biochem. 269 (15): 3619–31. doi:10.1046/j.1432-1033.2002.03038.x. PMID 12153558.
- Lundell I, Blomqvist AG, Berglund MM, et al. (1996). "Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.". J. Biol. Chem. 270 (49): 29123–8. doi:10.1074/jbc.270.49.29123. PMID 7493937.
- Bard JA, Walker MW, Branchek TA, Weinshank RL (1995). "Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.". J. Biol. Chem. 270 (45): 26762–5. doi:10.1074/jbc.270.45.26762. PMID 7592911.
- Yan H, Yang J, Marasco J, et al. (1996). "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4661–5. doi:10.1073/pnas.93.10.4661. PMC 39335. PMID 8643460. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=39335.
- Kawabe T, Muslin AJ, Korsmeyer SJ (1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint.". Nature 385 (6615): 454–8. doi:10.1038/385454a0. PMID 9009195.
- Darby K, Eyre HJ, Lapsys N, et al. (1998). "Assignment of the Y4 receptor gene (PPYR1) to human chromosome 10q11.2 and mouse chromosome 14.". Genomics 46 (3): 513–5. doi:10.1006/geno.1997.5071. PMID 9441761.
- Hsieh-Wilson LC, Allen PB, Watanabe T, et al. (1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1.". Biochemistry 38 (14): 4365–73. doi:10.1021/bi982900m. PMID 10194355.
- Smith FD, Oxford GS, Milgram SL (1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein.". J. Biol. Chem. 274 (28): 19894–900. doi:10.1074/jbc.274.28.19894. PMID 10391935.
- Marx SO, Reiken S, Hisamatsu Y, et al. (2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.". Cell 101 (4): 365–76. doi:10.1016/S0092-8674(00)80847-8. PMID 10830164.
- Connor JH, Weiser DC, Li S, et al. (2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.". Mol. Cell. Biol. 21 (20): 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. PMC 99861. PMID 11564868. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99861.
- Cavadas C, Silva AP, Mosimann F, et al. (2001). "NPY regulates catecholamine secretion from human adrenal chromaffin cells.". J. Clin. Endocrinol. Metab. 86 (12): 5956–63. doi:10.1210/jc.86.12.5956. PMID 11739470.
- Cox HM, Tough IR (2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa.". Br. J. Pharmacol. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMC 1573267. PMID 11906964. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1573267.
- Wu DY, Tkachuck DC, Roberson RS, Schubach WH (2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity.". J. Biol. Chem. 277 (31): 27706–15. doi:10.1074/jbc.M200955200. PMID 12016208.
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