Parabrachial nucleus

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Brain: Parabrachial nucleus
NeuroNames	ancil-2137625543

The parabrachial nucleus (PBN) is a region in the pons that is related to the ascending reticular activating system (ARAS). It can be subdivided into the lateral parabrachial nucleus and the medial parabrachial nucleus. The PBN connects the reticular formation to the thalamic relay nuclei as well as the intralaminar and related nuclei.

Function

In rodents, the PBN is the second relay nucleus in gustatory (taste) processing. Fibers from the nucleus of solitary tract connect to gustatory centers in the PBN, which sends projects along two pathways for taste processing. The first connects the PBN to the ventroposterior medial nucleus of the thalamus and the other connects the PBN to the central nucleus of the amygdala and lateral hypothalamus. Lesions of the PBN disrupt conditioned taste aversion.

A lesion to this pathway can lead to decreased consciousness.

External links

BrainMaps at UCDavis parabrachial%20nucleus

Human brain, rhombencephalon, metencephalon: pons (TA A14.1.05.101–604, GA 9.785)

Dorsal/
(tegmentum)

Surface	Cerebellopontine angle · Superior medullary velum · Sulcus limitans · Medial eminence · Facial colliculus

White: Sensory/ascending	Trapezoid body/VIII · Trigeminal lemniscus (Dorsal trigeminal tract, Ventral trigeminal tract) · Medial lemniscus · Lateral lemniscus MLF, III, IV and VI: Vestibulo-oculomotor fibers Anterior trigeminothalamic tract · Central tegmental tract

White: Motor/descending	ICP (Vestibulocerebellar tract) MLF, III, IV and VI: Vestibulospinal tract (Medial vestibulospinal tract, Lateral vestibulospinal tract)

Grey: Cranial nuclei	afferent: GSA: Principal V/Spinal V · VIII-c (Dorsal, Anterior)/VIII-v (Superior) efferent: SVE: Motor V · VII · GSE: VI · GVE: VII: Superior salivary nucleus

Other grey	Apneustic center · Pneumotaxic center (Medial parabrachial nucleus) · Lateral parabrachial nucleus · Superior olivary nucleus · Caerulean nucleus

Ventral/
(base)

Grey	Pontine nuclei

White: Motor/descending	Corticospinal tract · Corticobulbar tract · Corticopontine fibers MCP (Pontocerebellar fibers)

Surface	Basilar sulcus

Other grey: Raphe/
reticular

Reticular formation (Caudal, Oral, Tegmental, Paramedian) · Raphe nuclei (Median)

M: CNS

anat(n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp

noco(m/d/e/h/v/s)/cong/tumr, sysi/epon, injr

proc, drug(N1A/2AB/C/3/4/7A/B/C/D)

Sensory system: Gustatory system (TA 15.4, GA 10.991)

Tongue

Taste bud (Vallate papilla, Foliate papilla, Fungiform papilla) · Filiform papilla

Path

medulla: Solitary tract (VII, IX, X) · Solitary nucleus (Gustatory nucleus)

pons: Central tegmental tract · Parabrachial nucleus (Hypothalamus, Amygdala)

thalamus: Ventral posteromedial nucleus

cerebrum: Posterior limb of internal capsule · Gustatory cortex

Other

Basic tastes

M: TST

anat, phys

sysi

–

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