PC12 is a cell line derived from a pheochromocytoma of the rat adrenal medulla.[1][2] PC12 cells stop dividing and terminally differentiate when treated with nerve growth factor.[3] This makes PC12 cells useful as a model system for neuronal differentiation.
See also
References
- ^ Greene LA, Tischler AS (July 1976). "Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor". Proc. Natl. Acad. Sci. U.S.A. 73 (7): 2424–8. doi:. PMID 1065897.
- ^ "PC-12/CRL-1721 cell line". LGC Promochem: Cell Biology Collection. American Type Culture Collection. http://www.lgcpromochem-atcc.com/common/catalog/numSearch/numResults.cfm?atccNum=CRL-1721. Retrieved on 2008-08-15.
- ^ Center for Cancer Education
External links
- Wikipedia articles containing the term "PC12 cells" [1]
- table of common cell lines including PC12 [2], from Alberts 4th edition at NCBI bookshelf
- Ras function was partially elucidated using PC12 cell line [3], from section in Cancer Medicine textbook
- Section on neural transmission [4] has several references to PC12 cell line
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