 |
|
|
Pentamorphone
|
|
| Systematic (IUPAC) name | |
| 4,5α-epoxy- 3-hydroxy- 14β-pentylamino- 17-methyl- 7,8-didehydro- morphinan- 6-one | |
| Identifiers | |
| CAS number | 68616-83-1 |
| ATC code | none |
| PubChem | 5464186 |
| Chemical data | |
| Formula | C22H28N2O3 |
| Mol. mass | 368.469 g/mol |
| SMILES | eMolecules & PubChem |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ?
|
Pentamorphone (14β-pentylaminomorphinone, RX-77989) is a semi-synthetic opiate derivative related to compounds such as morphine, hydromorphone and oxymorphone. Developed in 1984, it is a potent opioid analgesic several times stronger than fentanyl, and with a similarly fast onset of effects and short duration of action.[1][2] It was found to produce relatively little respiratory depression compared to other potent opioid agonists,[3] but its analgesic effects were somewhat disappointing in human trials,[4] and while pentamorphone had some slight advantages over fentanyl[5] these were not sufficient to warrant its introduction into clinical use. In addition, pentamorphone has a particularly high dependence liability, even when compared to other potent narcotic analgesics such as morphine and heroin.
References
- ^ Glass PS, Camporesi EM, Shafron D, Quill T, Reves JG. Evaluation of pentamorphone in humans: a new potent opiate. Anesthesia and Analgesia. 1989 Mar;68(3):302-7. PMID 2465708
- ^ Rudo FG, Wynn RL, Ossipov M, Ford RD, Kutcher BA, Carter A, Spaulding TC. Antinociceptive activity of pentamorphone, a 14-beta-aminomorphinone derivative, compared to fentanyl and morphine. Anesthesia and Analgesia. 1989 Oct;69(4):450-6. PMID 2476953
- ^ Afifi MS, Glass PS, Cohen NA, Shook JE, Camporesi EM. Depression of ventilatory responses to hypoxia and hypercapnia after pentamorphone. Anesthesia and Analgesia. 1990 Oct;71(4):377-83. PMID 1698039
- ^ Wong HY, Parker RK, Fragen R, White PF. Pentamorphone for management of postoperative pain. Anesthesia and Analgesia. 1991 May;72(5):656-60. PMID 1708214
- ^ Kelly WB, Howie MB, Romanelli VA, Duarte JA, Rezaei H, McSweeney TD. A comparison of pentamorphone and fentanyl in balanced anaesthesia during general surgery. Canadian Journal of Anaesthesia. 1994 Aug;41(8):703-9. PMID 7522977
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 |
This pharmacology-related article is a stub. You can help Wikipedia by expanding it. |
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
