They lose there say, they lose there voice in society!

47% of people will lose a friend to drugs

People can lose some their constitutional rights, but not without due process. For instance, people can lose their right to freedom by being convicted of a crime and going to prison. People who are convicted of a felony can lose their right to vote.

People lose their homes, they lose their pets and lose their family

Lose is the opposite of win. If someone says "you lose," they mean you didn't win.