Perphenazine; Amitriptyline tablets

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What are perphenazine; amitriptyline tablets?

PERPHENAZINE; AMITRIPTYLINE (Triavil®, Etrafon®, Etrafon Forte®) is used to treat depression that may be accompanied by anxiety or agitation. Your prescriber or health care professional may prescribe amitriptyline for other conditions, such as relief from pain. Generic perphenazine; amitriptyline tablets are available.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• an alcohol problem
• asthma, difficulty breathing
• blood disorders or disease
• diabetes
• difficulty passing urine, prostate trouble
• glaucoma
• having intramuscular injections
• head injury
• heart disease or previous heart attack
• liver disease
• low blood level of calcium
• over active thyroid
• Parkinson's disease
• Reye's syndrome
• schizophrenia
• seizures (convulsions)
• stomach disease or peptic ulcers
• an unusual or allergic reaction to perphenazine, amitriptyline, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I take this medicine?

Take perphenazine; amitriptyline tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. Take this drug with food or milk if it upsets your stomach. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your prescriber's advice.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

Adolescents and elderly patients over 65 years old may have a stronger reaction to this medicine and may need smaller doses.

What drug(s) may interact with perphenazine; amitriptyline?

Perphenazine; amitriptyline can interact with many other medicines. Some interactions can be very important. Make sure your prescriber or health care professional knows about all other medicines you are taking. Many important interactions are listed below:

Do not take perphenazine; amitriptyline with any of the following medications:
• astemizole (Hismanal®)
• cisapride (Propulsid®)
• probucol
• terfenadine (Seldane®)
• medicines called MAO inhibitors-phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®), selegiline (Eldepryl®)
• other medicines for mental depression (may be duplicate therapies or cause additive side effects)
• other medicines for mental or mood problems and psychotic disturbances (may be duplicate therapies or cause additive side effects)

Perphenazine; Amitriptyline also interact with any of the following medications:
• alcohol
• antacids
• atropine and related drugs like hyoscyamine, scopolamine, tolterodine and others
• barbiturate medicines for inducing sleep or treating seizures (convulsions), such as phenobarbital
• blood thinners, such as warfarin
• bromocriptine
• bupropion
• cimetidine
• clonidine
• cocaine
• delavirdine
• diphenoxylate
• disulfiram
• donepezil
• doxercalciferol
• drugs for treating HIV infection
• female hormones, including contraceptive or birth control pills and estrogen
• galantamine
• herbs and dietary supplements like ephedra (Ma huang), kava kava, SAM-e, St. John's wort, valerian, or others
• imatinib, STI-571
• kaolin; pectin
• labetalol
• levodopa and other medicines for movement problems like Parkinson's disease
• lithium
• medicines for anxiety or sleeping problems
• medicines for colds, flu and breathing difficulties, like pseudoephedrine
• medicines for hay fever or allergies (antihistamines)
• medicines for weight loss or appetite control
• medicines used to regulate abnormal heartbeat or to treat other heart conditions (examples: amiodarone, bepridil, disopyramide, dofetilide, flecainide, ibutilide, mibefradil, procainamide, quinidine, and others)
• metoclopramide
• muscle relaxants, like cyclobenzaprine
• prescription pain medications like morphine, codeine, tramadol and others
• procarbazine
• seizure (convulsion) or epilepsy medicine such as carbamazepine or phenytoin
• stimulants like dexmethylphenidate or methylphenidate
• some antibiotics (examples: erythromycin, gatifloxacin, levofloxacin, linezolid, moxifloxacin, sotalol, sparfloxacin)
• tacrine
• thyroid hormones such as levothyroxine

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking perphenazine; amitriptyline?

Visit your prescriber or health care professional for regular checks on your progress. It may take several weeks before you feel the full effect of this medicine.

If you have been taking this medicine regularly for some time, do not suddenly stop taking it. You must gradually reduce the dose or you may get severe side effects. Ask your prescriber or health care professional for advice. Even after you stop taking perphenazine; amitriptyline it can still affect your body for several days.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may increase dizziness and drowsiness. Avoid alcoholic drinks.

Do not treat yourself for coughs, colds or allergies without asking your prescriber or health care professional for advice. Some ingredients can increase possible side effects.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water will help.

This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your ophthalmologist if the problem does not go away or is severe.

This medicine may make your skin more sensitive to the sun. Keep out of the sun, or wear protective clothing outdoors and use a sunscreen. Do not use sun lamps or sun tanning beds or booths.

If you are diabetic, check your blood sugar more often than usual, especially during the first few weeks of treatment with perphenazine; amitriptyline. Perphenazine; amitriptyline can affect blood glucose (sugar) levels. Call your prescriber or health care professional for advice if you notice a change in the results of blood or urine glucose tests.

If you are going to have surgery or will need a procedure that uses contrast agents, tell your prescriber or health care professional that you are taking this medicine.

What side effects may I notice from taking perphenazine; amitriptyline?

Side effects that you should report to your prescriber or health care professional as soon as possible:
• abnormal production of milk in females
• blurred vision or eye pain
• breast enlargement in both males and females
• confusion, hallucinations (seeing or hearing things that are not really there)
• difficulty breathing
• fainting spells
• fever with increased sweating
• high or low blood pressure
• irregular or fast, pounding heartbeat, palpitations
• menstrual cycle changes
• muscle stiffness, or spasms
• pain or difficulty passing urine, loss of bladder control
• seizures (convulsions)
• sexual difficulties (decreased sexual ability or desire, difficulty ejaculating)
• stomach pain
• swelling of the testicles
• tingling, pain, or numbness in the feet or hands
• tremors or shakiness
• uncontrolled movements of the mouth, head, hands, feet, shoulders, eyelids or other unusual muscle movements
• unusual weakness or tiredness
• yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• anxiety
• constipation or diarrhea
• difficulties falling asleep
• drowsiness or dizziness
• dry mouth
• headache
• increased sensitivity of the skin to sun or ultraviolet light
• increased sweating
• loss of appetite
• nausea, vomiting
• skin rash or itching
• weight gain or loss

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.