Peruvoside

Peruvoside

Systematic (IUPAC) name
(3β,5β,8ξ,9ξ)- 3-[(6-deoxy- 3-O-methyl- α-D- glycero- hexopyranosyl)oxy]- 14-hydroxy- 19-oxocard- 20(22)enolide
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	1182-87-2
ATC code	C01AX02
PubChem	CID 14449
ChemSpider	16498835 Y
ChEMBL	CHEMBL1075790 Y
Synonyms	(3S,5R,10R,13R,14S,17R)- 3-[(2S,5R)- 3,5-dihydroxy- 4-methoxy- 6-methyloxan- 2-yl]oxy- 14-hydroxy- 13-methyl- 17-(5-oxo-2H-furan-3-yl)- 1,2,3,4,5,6,7,8,9,11,12,15,16,17- tetradecahydrocyclopenta[a]phenanthrene- 10-carbaldehyde
Chemical data
Formula	C30H44O9
Mol. mass	548.665 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C30H44O9/c1-16-24(33)26(36-3)25(34)27(38-16)39-19-6-10-29(15-31)18(13-19)4-5-22-21(29)7-9-28(2)20(8-11-30(22,28)35)17-12-23(32)37-14-17/h12,15-16,18-22,24-27,33-35H,4-11,13-14H2,1-3H3/t16-,18+,19-,20+,21-,22+,24-,25-,26+,27-,28+,29+,30-/m0/s1 Y Key:PMTSPAGBAFCORP-HBUONDEYSA-N Y
Y(what is this?)  (verify)

Peruvoside (or cannogenin thevetoside) is a cardiac glycoside^[1] for heart failure.^[2]

It is derived from Thevetia neriifolia.^[2]

References

1. ^ Peruvoside and Other Cardiotonic Glycoside[s] of Thevetia nereifolia; Chemical, Pharmacological, and Clinical Studies. Arora, R. B.; Rangaswami, S. (1972), Publisher: (Thomson, New Delhi, India)
2. ^ ^{a b} Bhatia ML, Manchanda SC, Roy SB (September 1970). "Haemodynamic studies with peruvoside in human congestive heart failure". Br Med J 3 (5725): 740–3. doi:10.1136/bmj.3.5725.740. PMC 1701679. PMID 4919553. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1701679. 

v · d · eCardiac glycosides (C01A) Bufadienolides Bufo Arenobufagin • Bufotalin • Cinobufagin • Marinobufagin Scilla Proscillaridin • Scilliroside Cardenolides Digitalis Acetyldigitoxin • Acetyldigoxin • Digitoxin# • Digoxin • Lanatoside C • Deslanoside • Metildigoxin • Gitoformate Kalanchoe Daigremontianin Strophantus Ouabain (g-Strophanthin) • k-Strophanthin • Cymarin Thevetia Peruvoside #WHO-EM. ‡Withdrawn from market. Clinical trials: †Phase III. §Never to phase III M: HRT anat/phys/devp noco/cong/tumr, sysi/epon, injr proc, drug (C1A/1B/1C/1D), blte

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