Phenylethanolamine N-methyltransferase: Information from Answers.com

phenylethanolamine N-methyltransferase
Identifiers
Symbol	PNMT
Alt. Symbols	PENT
Entrez	5409
HUGO	9160
OMIM	171190
RefSeq	NM_002686
UniProt	P11086
Other data
EC number	2.1.1.28
Locus	Chr. 17 q21-q22

Phenylethanolamine N-methyltransferase (PNMT) is an enzyme found in the adrenal medulla that converts Norepinephrine (Noradrenaline) to Epinephrine (Adrenaline).

PNMT is positively influenced by cortisol, which is produced in the adrenal cortex.

S-adenosyl-L-methionine ('SAM') is a required cofactor.^[1]

PNMT converts the last step in the synthesis of epinephrine

References

^ Wong DL, Lesage A, Siddall B, Funder JW (November 1992). "Glucocorticoid regulation of phenylethanolamine N-methyltransferase in vivo". The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 6 (14): 3310–5. PMID 1426768. http://www.fasebj.org/cgi/content/abstract/6/14/3310.

Transferase: one carbon transferases (EC 2.1)

N-	Histamine N-methyltransferase - Phenylethanolamine N-methyltransferase - Tryptamine N-methyltransferase - Phosphatidylethanolamine N-methyltransferase

O-	5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase - Catechol-O-methyl transferase

Homocysteine	Betaine-homocysteine methyltransferase - Homocysteine methyltransferase - 5-Methyltetrahydrofolate-homocysteine methyltransferase

Other	Phosphatidyl ethanolamine methyltransferase - DNMT3B - Histone methyltransferase - Thymidylate synthase - DNA methyltransferase - Thiopurine methyltransferase

Hydroxymethyltransferase	Serine hydroxymethyltransferase - 3-methyl-2-oxobutanoate hydroxymethyltransferase

Formyltransferase	Phosphoribosylglycinamide formyltransferase - Inosine monophosphate synthase - Glutamate formimidoyltransferase

Other	Aminomethyltransferase

Carboxy	methylmalonyl-CoA carboxytransferase

Carbamoyl	Aspartate carbamoyltransferase - Ornithine carbamoyltransferase - Oxamate carbamoyltransferase - Putrescine carbamoyltransferase - 3-hydroxymethylcephem carbamoyltransferase - Lysine carbamoyltransferase - N-acetylornithine carbamoyltransferase

histidine→histamine	anabolism: Histidine decarboxylase catabolism: Histamine N-methyltransferase - Amine oxidase

tyrosine→dopamine→epinephrine	anabolism: Tyrosine hydroxylase - Aromatic L-amino acid decarboxylase - Dopamine beta hydroxylase - Phenylethanolamine N-methyltransferase catabolism: Catechol-O-methyl transferase - Monoamine oxidase

glutamate→GABA	anabolism: Glutamate decarboxylase catabolism: 4-aminobutyrate aminotransferase - 4-aminobutyrate transaminase

tryptophan→serotonin→melatonin	Tryptophan hydroxylase - Aromatic L-amino acid decarboxylase - Acetylserotonin O-methyltransferase

see also intermediates

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	RU28362
	Phosphatidyl ethanolamine methyltransferase
	Aminomethyltransferase