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phosphatidylethanolamine N-methyltransferase
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| Identifiers | |
| Symbol | PEMT |
| Entrez | 10400 |
| HUGO | 8830 |
| OMIM | 602391 |
| RefSeq | NM_007169 |
| UniProt | Q9UBM1 |
| Other data | |
| EC number | 2.1.1.17 |
| Locus | Chr. 17 p11.2 |
Phosphatidyl ethanolamine methyltransferase also known as PEMT is an enzyme which in humans is encoded by the PEMT gene.[1][2][3]
Contents |
Function
The PEMT enzyme converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. The protein localizes to the endoplasmic reticulum and mitochondria-associated membranes. The gene is within the Smith-Magenis syndrome region on chromosome 17.[3]
See also
References
- ^ Walkey CJ, Shields DJ, Vance DE (January 1999). "Identification of three novel cDNAs for human phosphatidylethanolamine N-methyltransferase and localization of the human gene on chromosome 17p11.2". Biochim. Biophys. Acta 1436 (3): 405–12. PMID 9989271.
- ^ Vance DE, Li Z, Jacobs RL (November 2007). "Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology". J. Biol. Chem. 282 (46): 33237–41. doi:. PMID 17881348.
- ^ a b "Entrez Gene: PEMT". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10400.
External links
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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