| Phosphatidylinositol (3,4,5)-trisphosphate | |
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| Other names | PI(3,4,5)P3, PtdIns(3,4,5)P3 |
| Properties | |
| Molecular formula | C47H86O22P4 |
| Molar mass | 1126.46 g/mol, neutral with fatty acid composition - 18:0, 20:4 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references |
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Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3) commonly abbreviated to PIP3 is the product of the class I phosphoinositide 3-kinases (PI 3-kinases) phosphorylation on phosphatidylinositol (4,5)-bisphosphate (PIP2).
Function
PIP3 is a part of the phosphatidylinositol bisphosphate (PIP2) Lipid signaling Second messenger system. After phosphorylation by PI3K, PIP3 has been shown to enhance cell survival.[1]
PtdIns(3,4,5)P3 is dephophosphorylated by the phosphatase, PTEN on the 3 position, generating PI(4,5)P2, and by SHIPs (SH2-containing inositol phosphatase) on the 5' position of the inositol ring, producing PI(3,4)P2.
The PH domain in a number of proteins binds to PtdIns(3,4,5)P3. Such proteins include Akt/PKB, PDK1, Btk1 and ARNO. The generation of PtdIns(3,4,5)P3 at the plasma membrane upon the activation of class I PI 3-kinases causes these proteins to translocate to the plasma membrane and accordingly affects their activity.
The PH domain allows binding between PtdIns(3,4,5)P3 and G-protein coupled receptor kinases (GRKs). This enhances the binding of the GRK to the plasma membrane.
References
- ^ Prokazova, N. et al. Lipid second messengers and cell signaling in vascular wall. Biochemistry (Mosc.) 72, 797-808 (2007).
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