Phosphomevalonate kinase

phosphomevalonate kinase
Identifiers
Symbol	PMVK
Entrez	10654
HUGO	9141
OMIM	607622
RefSeq	NM_006556
UniProt	Q15126
Other data
EC number	2.7.4.2
Locus	Chr. 1 p13-q23

Phosphomevalonate kinase is an enzyme in the mevalonate pathway.

Mevalonate pathway

External links

• MeSH Phosphomevalonate+kinase

This biochemistry article is a stub. You can help Wikipedia by expanding it. v • d • e

v • d • e Transferases: Phosphotransferases/kinases (EC 2.7) 2.7.1: OH acceptor Hexo- · Gluco- · Fructo- (Hepatic) · Galacto- · Phosphofructo- (1, Liver, Muscle, Platelet, 2) · Riboflavin · Shikimate · Thymidine (ADP-thymidine) · NAD+ · Glycerol · Pantothenate · Mevalonate · Pyruvate · Deoxycytidine · PFP · Diacylglycerol · Bruton's tyrosine · Phosphoinositide 3 (Class I PI 3, Class II PI 3) · Sphingosine · Glucose-1,6-bisphosphate synthase 2.7.2: COOH acceptor Phosphoglycerate · Aspartate 2.7.3: N acceptor Creatine 2.7.4: PO4 acceptor Phosphomevalonate · Adenylate · Nucleoside-diphosphate 2.7.6: P2O7 Ribose-phosphate diphosphokinase · Thiamine pyrophosphokinase 2.7.7: nucleotidyl- Polymerase DNA polymerase DNA-directed DNA polymerase: DNA polymerase I · DNA polymerase II · DNA polymerase III holoenzyme · Reverse transcriptase (Telomerase) DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase RNA nucleotidyltransferase RNA polymerase/DNA-directed RNA polymerase: RNA polymerase I · RNA polymerase II · RNA polymerase III · RNA polymerase IV · Primase · RNA-dependent RNA polymerase PNPase Other Recombinase (Integrase) · RNase PH · UDP-glucose pyrophosphorylase · Galactose-1-phosphate uridylyltransferase · Transposase 2.7.8: other phos. N-acetylglucosamine-1-phosphate transferase 2.7.10-11: protein Tyrosine · Serine/threonine-specific 2.7.12: dual-specificity Dual-specificity kinase · Mitogen-activated protein kinase kinase 2.7.13 protein-histidine Protein-histidine pros-kinase · Protein-histidine tele-kinase · Histidine kinase

v • d • e Metabolism: lipid metabolism · ketones/cholesterol synthesis enzymes/steroid metabolism Mevalonate pathway To HMG-CoA Acetyl-Coenzyme A acetyltransferase · HMG-CoA synthase (regulated step) Ketogenesis HMG-CoA lyase · 3-hydroxybutyrate dehydrogenase · Thiophorase To Mevalonic acid HMG-CoA reductase To DMAPP Mevalonate kinase · Phosphomevalonate kinase · Pyrophosphomevalonate decarboxylase · Isopentenyl-diphosphate delta isomerase Geranyl- Dimethylallyltranstransferase · Geranyl pyrophosphate To cholesterol To lanosterol Farnesyl-diphosphate farnesyltransferase · Squalene monooxygenase · Lanosterol synthase 7-Dehydrocholesterol path Lanosterol 14α-demethylase · Sterol-C5-desaturase-like · 7-Dehydrocholesterol reductase Desmosterol path 24-dehydrocholesterol reductase To Bile acids Cholesterol 7α-hydroxylase · Sterol 27-hydroxylase Steroidogenesis To pregnenolone Side-chain cleavage To corticosteroids aldosterone: 18-hydroxylase cortisol/cortisone: 17α-hydroxylase · 11β dehydrogenase (HSD11B1, HSD11B2) both: 3β dehydrogenase · 21α-hydroxylase · 11β-hydroxylase To sex hormones To androgens 17α-hydroxylase/17,20 lyase · 3β dehydrogenase · 17β dehydrogenase · 5α reductase To estrogens Aromatase Other/ungrouped Steroid sulfatase · Steroidogenic acute regulatory protein see also intermediates, disorders

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