Phosphotransferase: Definition from Answers.com

Phosphotransferases are a category of enzymes (EC number 2.7) which catalyze phosphorylation reactions. The general form of the reactions they catalyze is:

A—P + B ⇔ B—P + A

Where P is a phosphate group and A and B are the donating and accepting molecules, respectively.

Phosphostransferase system

The phosphotransferase system (PTS) is a complex group translocation system present in many bacteria. The PTS transports sugars (such as glucose, mannose, and mannitol) into the cell. The first step of this reaction is phosphorylation of the substrate via phosphotransferase during transport. In the case of glucose, the product of this phosphorylation is Glucose-6-Phosphate (Glu-6P). Due to the negative charge of the phosphate, this Glu-6P can no longer freely leave the cell. This is the first reaction of glycolysis, which degrades the sugar to pyruvate.

External links

MeSH Phosphotransferases

This enzyme-related article is a stub. You can help Wikipedia by expanding it.

v • d • e Proteins: enzymes

Topics	Active site - Allosteric regulation - Binding site - Catalytically perfect enzyme - Coenzyme - Cofactor - Cooperativity - EC number Enzyme catalysis - Enzyme inhibitor - Enzyme kinetics - Lineweaver–Burk plot - Michaelis–Menten kinetics - List of enzymes

Types	EC1 Oxidoreductases/list - EC2 Transferases/list - EC3 Hydrolases/list - EC4 Lyases/list - EC5 Isomerases/list - EC6 Ligases/list

Transferases: Phosphotransferases/kinases (EC 2.7)

2.7.1: OH acceptor

Hexo- · Gluco- · Fructo- (Hepatic) · Galacto- · Phosphofructo- (1, Liver, Muscle, Platelet, 2) · Riboflavin · Shikimate · Thymidine (ADP-thymidine) · NAD⁺ · Glycerol · Pantothenate · Mevalonate · Pyruvate · Deoxycytidine · PFP · Diacylglycerol · Bruton's tyrosine · Phosphoinositide 3 (Class I PI 3, Class II PI 3) · Sphingosine · Glucose-1,6-bisphosphate synthase

2.7.2: COOH acceptor

Phosphoglycerate · Aspartate

2.7.3: N acceptor

Creatine

2.7.4: PO₄ acceptor

Phosphomevalonate · Adenylate · Nucleoside-diphosphate

2.7.6: P₂O₇

Ribose-phosphate diphosphokinase · Thiamine pyrophosphokinase

2.7.7: nucleotidyl-

Polymerase

DNA polymerase	DNA-directed DNA polymerase: DNA polymerase I · DNA polymerase II · DNA polymerase III holoenzyme · Reverse transcriptase (Telomerase) DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase

RNA nucleotidyltransferase	RNA polymerase/DNA-directed RNA polymerase: RNA polymerase I · RNA polymerase II · RNA polymerase III · RNA polymerase IV · Primase · RNA-dependent RNA polymerase PNPase

Other

Recombinase (Integrase) · RNase PH · UDP-glucose pyrophosphorylase · Galactose-1-phosphate uridylyltransferase · Transposase

2.7.8: other phos.

N-acetylglucosamine-1-phosphate transferase

2.7.10-11: protein

Tyrosine · Serine/threonine-specific

2.7.12: dual-specificity

Dual-specificity kinase · Mitogen-activated protein kinase kinase

2.7.13 protein-histidine

Protein-histidine pros-kinase · Protein-histidine tele-kinase · Histidine kinase

This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)

Donate to Wikimedia

		Medical Dictionary. The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Read more
		Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more
		Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Phosphotransferase". Read more