Physalaemin
Oxford Dictionary of Biochemistry:
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physalaemin
Glp-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2; an 11-residue peptide amide tachykinin from the skin of the amphibian Physalaemus fuscumaculatus. It is more potent than eledoisin and substance P in some assay systems, and is useful in the study of receptors for substance P.
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Physalaemin
| Physalaemin | |
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| Identifiers | |
| CAS number | 2507-24-6  |
| PubChem | 17268 |
| MeSH | Physalaemin |
| ChEMBL | CHEMBL415235  |
| Properties | |
| Molecular formula | C58H84N14O16S |
| Molar mass | 1265.44 g/mol |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Physalaemin is a tachykinin peptide obtained from the Physalaemus frog, closely related to substance P. Its structure was first elucidated in 1964.[1][2]
Like all tachykinins, physalaemin is a sialagogue (increases salivation) and a potent vasodilator with hypotensive effects.[3]
References
- ^ Erspaemer V, Anastasi A, Bertaccini G, Cei JM (1964). "Structure and pharmacological actions of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus". Experientia 20 (9): 489–90. doi:10.1007/BF02154064. PMID 5857249.
- ^ Anastasi A, Erspamer V, Cei JM (1964). "Isolation and amino acid sequence of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus". Arch Biochem Biophys 108 (2): 341–8. doi:10.1016/0003-9861(64)90395-9. PMID 14240587.
- ^ Severini C, Improta G, Falconieri-Erspamer G, Salvadori S, Erspamer V (2002). "The tachykinin peptide family". Pharmacol Rev 54 (2): 285–322. doi:10.1124/pr.54.2.285. PMID 12037144. Free full text
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Oxford Dictionary of Biochemistry
Oxford University Press. Oxford Dictionary of Biochemistry and Molecular Biology © 1997, 2000, 2006 All rights reserved.
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