Piperonyl butoxide
Drug Info:
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Pyrethrins; Piperonyl Butoxide
Brand names: A-200® Lice Treatment Kit, A-200® Lice Treatment Solution, Clear® Total Lice System, Lice-Aid® Shampoo, Pronto® Lice Kill System, Pronto® Plus Complete Lice Removal Kit, Pronto® Plus Lice Killing Mousse Shampoo Kit, Pronto® Shampoo Kit, Pronto® Spray, Pronto® with Metal Comb, Pyrinil® Lice Control Kit, Pyrinyl® , Pyrinyl® Shampoo, Rid®, Rid® Mousse, Rid® Pediculicide, Rid® Shampoo/Spray Kit
Chemical formula:
- Drug Forms:
- Pyrethrins; Piperonyl Butoxide Shampoo (below)
- Pyrethrins; Piperonyl Butoxide Mousse
- Pyrethrins; Piperonyl Butoxide Gel, Lotion or Solution
- Diazolidinyl urea, Glycolic Acid, Hydroxyethyl Cellulose, Methylparaben, polyquatemium, Potassium hydroxide, Propylene Glycol, Propylparaben, Water Topical gel, Piperonyl Butoxide, Pyrethrins Shampoo
- Piperonyl Butoxide, Pyrethrins Shampoo
- Piperonyl Butoxide, Pyrethrum Extract Shampoo
- Piperonyl Butoxide, Pyrethrum Extract Topical foam
- Hydroxyethyl Cellulose, Distilled Water, Glycerin, Polysorbate 20, DMDM Hydantoin, Iodopropynyl Butylcarbamate, Cocamine oxide Topical gel, Piperonyl Butoxide, Pyrethrum Extract Shampoo
- Espa�ol:
- Tratamiento de los piojos Champú, Tratamiento de los piojos Gel tópico
- Tratamiento de los piojos Champú, Tratamiento de los piojos Gel tópico
- Tratamiento de los piojos, Champú
- Tratamiento de los piojos, Espuma tópica
- Botiquín de tratamiento para piojos
Pyrethrins; Piperonyl Butoxide Shampoo
What is Pyrethrins; Piperonyl Butoxide shampoo?
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:• asthma
• an unusual reaction to pyrethrins, piperonyl butoxide, other medicines, foods, dyes, ragweed, chrysanthemums, kerosene, or preservatives
• pregnant or trying to get pregnant
• breast-feeding
How should this medicine be used?
Use enough of this medicine on dry hair and scalp or skin to thoroughly wet the hair and cover all of the affected area. This medicine should not be used on wet hair because it will not work as well. For head lice, use this medicine on the back of the neck and behind the ears first, then move to the rest of the hair and scalp. Be sure to cover all parts of the hair from the roots to the tips. Keep this medicine on your hair or affected area for 10 minutes. After 10 minutes, use a small amount of water to work this medicine into the hair and skin until a lather forms. Rinse and dry with a clean towel. Using a nit comb, remove any of the remaining lice or nits. Repeat this procedure once in 7—10 days.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
What if I miss a dose?
What drug(s) may interact with Pyrethrins; Piperonyl Butoxide?
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.What should I watch for while taking Pyrethrins; Piperonyl Butoxide?
Head lice can be spread from one person to another by direct contact with clothing, hats, scarves, bedding, towels, washcloths, hairbrushes, and combs. All members of your household should be examined for head lice and should receive treatment if they are found to be infected. If you have any questions about this, check with your doctor or health care professional.
To prevent reinfection or spreading of the infection, the following steps should be taken: Machine wash all clothing, bedding, towels, and washcloths in very hot water and dry them using the hot cycle of a dryer for at least 20 minutes. Clothing or bedding that cannot be washed should be dry cleaned or sealed in an airtight plastic bag for 4 weeks. Shampoo any wigs or hairpieces. You should also wash all hairbrushes and combs in very hot soapy water (above 130 F) for 5—10 minutes. Do not share your hairbrushes or combs with other people. Wash all toys in very hot water (above 130 F) for 5—10 minutes or seal in an airtight plastic bag for 4 weeks. Also, clean the house or room by vacuuming furniture, rugs, and floors. For cases of pubic lice, sexual partners should be treated at the same time to prevent reinfection.
What side effects may I notice from receiving Pyrethrins; Piperonyl Butoxide?
Side effects that you should report to your prescriber or health care professional as soon as possible:• difficulty breathing (especially if you have asthma)
• eye irritation
• severe itching or scalp irritation that does not go away
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• itching
• redness or mild swelling of the scalp
• stinging or burning
• tingling sensation
Where can I keep my medicine?
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from excessive heat. Do not refrigerate or freeze.
After treatment, throw away any unused medicine. Do not use this medicine after the expiration date on the package.
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
Related Videos:
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Piperonyl butoxide
Saunders Veterinary Dictionary:
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piperonyl butoxide
A synergist used with, and as an enhancer for, pyrethrum and rotenone in the control of ectoparasites.
Wikipedia on Answers.com:
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Piperonyl butoxide
| Piperonyl butoxide | |
|---|---|
 |
|
|
5-[2-(2-butoxyethoxy)ethoxymethyl] -6-propyl-1,3-benzodioxole |
|
| Identifiers | |
| CAS number | 51-03-6  |
| KEGG | C18880  |
| ChEMBL | CHEMBL1201131 |
| Jmol-3D images | Image 1 |
|
|
| Properties | |
| Molecular formula | C19H30O5 |
| Molar mass | 338.438 g/mol |
| Density | 1.05 g/cm3 |
| Boiling point |
180 °C (0.13 kPa) |
| Hazards | |
| Flash point | 170 °C |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
|
| Infobox references | |
Piperonyl butoxide (PBO) is an organic compound used as pesticide synergist, especially for pyrethroids and rotenone. It does not by itself have pesticidal properties. However, when added to insecticide mixtures, typically pyrethrin, pyrethroid, and carbamate insecticides, their potency is increased considerably.[1] It is a semisynthetic derivative of safrole.[2]
Mechanism of action
Piperonyl butoxide is a potent inhibitor of cytochrome P450 enzymes, which detoxify insecticides for many pests. Therefore, inhibiting the P450s allows higher unmetabolised systemic concentrations of the insecticide (such as pyrethroid) to remain within the target animal for a longer period.[3]
Safety and toxicity
Its acute oral and dermal toxicity in mammals is low[4] with LD50 of 7,500 to 6,150 mg/kg when orally administered to rats.[2]
A 2011 study found a significant association between piperonyl butoxide in personal air collected during the third trimester of pregnancy and delayed mental development at 36 months. Children who were more highly exposed in personal air samples (≥4.34 ng/m3) scored 3.9 points lower on the Mental Developmental Index than those with lower exposures. The lead researcher stated, "This drop in IQ points is similar to that observed in lead exposure. While perhaps not impacting an individual's overall function, it is educationally meaningful and could shift the distribution of children in the society who would be in need of early intervention services."[5]
References
- ^ National Pesticide Information Center - Piperonyl Butoxide General Fact Sheet
- ^ a b Robert L. Metcalf “Insect Control” in Ullmann’s Encyclopedia of Industrial Chemistry” Wiley-VCH, Weinheim, 2002. doi:10.1002/14356007.a14_263
- ^ Moores, G. D., Philippou, D., Borzatta, V., Trincia, P., Jewess, P., Gunning, R., Bingham, G. (2009). "An analogue of piperonyl butoxide facilitates the characterisation of metabolic resistance". Pest Manag. Sci. 65 (2): 150–154. doi:10.1002/ps.1661. PMID 18951417.
- ^ National Pesticide Information Center - Piperonyl Butoxide Technical Fact Sheet
- ^ Common Insecticide Used in Homes Associated With Delayed Mental Development of Young Children, ScienceDaily, Feb. 10, 2011
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Copyrights:
Saunders Veterinary Dictionary
Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.
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