Pituitary disease

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Pituitary disease
Classification and external resources
Pituitary
MeSH	D010900

A Pituitary disease is a disorder primarily affecting the pituitary gland.^[1]

The main disorders involving the pituitary gland are:

Condition	Direction	Hormone
Acromegaly	overproduction	growth hormone
Cushing's disease	overproduction	Adrenocorticotropic hormone
Growth hormone deficiency	underproduction	growth hormone
Syndrome of inappropriate antidiuretic hormone	overproduction	vasopressin
Diabetes insipidus (can also be nephrogenic)	underproduction	vasopressin
Sheehan syndrome	underproduction	any pituitary hormone
Pickardt-Fahlbusch-Syndrome	underproduction	any pituitary hormone, except prolactin, which is increased
Hyperpituitarism (most commonly pituitary adenoma)	overproduction	any pituitary hormone
Hypopituitarism	underproduction	any pituitary hormone

Hypothyroidism is caused by pituitary insufficiency in producing thyroid stimulating hormone (TSH) in less than 10% of hypothyroidism cases.^[2] Hyperthyroidism is caused by hypersecretion of TSH (almost always by a pituitary adenoma) in much less than 1 percent of hyperthyroidism cases.^[3]

References

^ "Overview of the Pituitary Gland: Pituitary Gland Disorders: Merck Manual Home Health Handbook". http://www.merckmanuals.com/home/hormonal_and_metabolic_disorders/pituitary_gland_disorders/overview_of_the_pituitary_gland.html. Retrieved 2009-04-04.
^ Page 358 in: Aminoff, Michael J. (2007). Neurology and General Medicine: Expert Consult: Online and Print. Edinburgh: Churchill Livingstone. ISBN 0-443-06707-4.
^ Thyrotropin (TSH)-secreting pituitary adenomas. By Roy E Weiss and Samuel Refetoff. Last literature review version 19.1: January 2011. This topic last updated: July 2, 2009

Endocrine pathology: endocrine diseases (E00–E35, 240–259)

Pancreas/
glucose
metabolism

Hypofunction	Diabetes mellitus types: (type 1, type 2, MODY 1 2 3 4 5 6) · complications (coma, angiopathy, ketoacidosis, nephropathy, neuropathy, retinopathy, cardiomyopathy) insulin receptor (Rabson–Mendenhall syndrome) · Insulin resistance

Hyperfunction	Hypoglycemia · beta cell (Hyperinsulinism) · G cell (Zollinger–Ellison syndrome)

Hypothalamic/
pituitary axes

Hypothalamus

gonadotropin (Kallmann syndrome, Adiposogenital dystrophy) · CRH (Tertiary adrenal insufficiency) · vasopressin (Neurogenic diabetes insipidus) · general (Hypothalamic hamartoma)

Pituitary

Hyperpituitarism	anterior (Acromegaly, Hyperprolactinaemia, Pituitary ACTH hypersecretion) · posterior (SIADH) · general (Nelson's syndrome)

Hypopituitarism	anterior (Kallmann syndrome, Growth hormone deficiency, ACTH deficiency/Secondary adrenal insufficiency) · posterior (Neurogenic diabetes insipidus) · general (Empty sella syndrome, Pituitary apoplexy, Sheehan's syndrome, Lymphocytic hypophysitis)

Thyroid

Hypothyroidism	Iodine deficiency · Cretinism (Congenital hypothyroidism) · Myxedema · Euthyroid sick syndrome

Hyperthyroidism	Hyperthyroxinemia (Thyroid hormone resistance, Familial dysalbuminemic hyperthyroxinemia) · Hashitoxicosis · Thyrotoxicosis factitia · Graves' disease

Thyroiditis	Acute infectious · Subacute (De Quervain's, Subacute lymphocytic) · Autoimmune/chronic (Hashimoto's, Postpartum, Riedel's)

Goitre	Endemic goitre · Toxic nodular goitre · Toxic multinodular goiter Thyroid nodule

Parathyroid

Hypoparathyroidism	Pseudohypoparathyroidism

Hyperparathyroidism	Primary · Secondary · Tertiary · Osteitis fibrosa cystica

Adrenal

Hyperfunction	aldosterone: Hyperaldosteronism/Primary aldosteronism (Conn syndrome, Bartter syndrome, Glucocorticoid remediable aldosteronism) · AME · Liddle's syndrome · 17α CAH cortisol: Cushing's syndrome (Pseudo-Cushing's syndrome) sex hormones: 21α CAH · 11β CAH

Hypofunction/ Adrenal insufficiency (Addison's, WF)	aldosterone: Hypoaldosteronism (21α CAH, 11β CAH) cortisol: CAH (Lipoid, 3β, 11β, 17α, 21α) sex hormones: 17α CAH

Gonads

ovarian: Polycystic ovary syndrome · Premature ovarian failure

testicular: enzymatic (5-alpha-reductase deficiency, 17-beta-hydroxysteroid dehydrogenase deficiency) · Androgen receptor (Androgen insensitivity syndrome)

general: Hypogonadism (Delayed puberty) · Hypergonadism (Precocious puberty)

Height

Gigantism · Dwarfism/Short stature (Laron syndrome, Psychosocial)

Multiple

Autoimmune polyendocrine syndrome (APS1, APS2) · Carcinoid syndrome · Multiple endocrine neoplasia (1, 2A, 2B) · Progeria (Werner syndrome, Acrogeria, Metageria) · Woodhouse-Sakati syndrome

M: END

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noco(d)/cong/tumr, sysi/epon

proc, drug (A10/H1/H2/H3/H5)

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