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Plakoglobin

 
Wikipedia: Plakoglobin
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Junction plakoglobin
Identifiers
Symbols JUP; DP3; CTNNG; DPIII; PDGB; PKGB
External IDs OMIM: 173325 MGI: 96650 HomoloGene: 1680
RNA expression pattern
PBB GE JUP 201015 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3728 16480
Ensembl ENSG00000173801 ENSMUSG00000001552
UniProt P14923 Q02257
RefSeq NM_002230 (mRNA) NM_010593 (mRNA)
NP_002221 (protein) NP_034723 (protein)
Location Chr 17:
37.16 - 37.2 Mb		 Chr 11:
100.19 - 100.21 Mb
PubMed search [1] [2]

Junction plakoglobin, also known as gamma-catenin or JUP, is a protein which in humans is encoded by the JUP gene.[1]

Contents

Function

This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat.[1]

Plakoglobin (gamma-catenin) was originally identified as a component of desmosomes, where it can bind to the cadherin family member desmoglein I. Plakoglobin also associates with classical cadherins such as E-cadherin; in that context, it was called gamma-catenin. Plakoglobin is O-glycosylated near its N-terminal destruction box.

Clinical significance

Mutation of the gene encoding plakoglobin has been implicated as one of the causes of the cardiomyopathy known as arrhythmogenic right ventricular dysplasia (ARVD).[2] The form of ARVD in which a mutated form of plakoglobin is present was first identified in a small cluster of families on the Greek island of Naxos, near the Turkish coast. This form of the disorder is autosomal recessive. The phenotype of the Naxos variant of ARVD is unique in that it involves the hair and skin as well as the right ventricle. Affected individuals have wooly, kinky hair; there is also palmar and plantar erythema at birth that progresses to keratosis as the palms and soles of the feet are used in crawling and walking. These findings co-segregate 100% with the development of ARVD by early adolescence.

Interactions

Plakoglobin has been shown to interact with Beta-catenin,[3][4] MUC1,[5] CDH1,[6][3][7][8][9] CDH2,[10][11] CDH3,[12] Catenin (cadherin-associated protein), alpha 1,[13][11][14] VE-cadherin,[15][16] Desmoglein 2,[17][18][19] Desmoplakin,[20][21] APC,[7][22] PTPRK[23] and PKP2.[24]

See also

External links

References

  1. ^ a b "Entrez Gene: JUP junction plakoglobin". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3728. 
  2. ^ Garcia-Gras E, Lombardi R, Giocondo MJ, et al. (July 2006). "Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy". J. Clin. Invest. 116 (7): 2012–21. doi:10.1172/JCI27751. PMID 16823493. PMC 1483165. http://dx.doi.org/10.1172/JCI27751. 
  3. ^ a b Hazan, R B; Norton L (Apr. 1998). "The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton". J. Biol. Chem. (UNITED STATES) 273 (15): 9078-84. ISSN 0021-9258. PMID 9535896. 
  4. ^ Kucerová, D; Sloncová E, Tuhácková Z, Vojtechová M, Sovová V (Dec. 2001). "Expression and interaction of different catenins in colorectal carcinoma cells". Int. J. Mol. Med. (Greece) 8 (6): 695-8. ISSN 1107-3756. PMID 11712088. 
  5. ^ Li, Yongqing; Yu Wei-Hsuan, Ren Jian, Chen Wen, Huang Lei, Kharbanda Surender, Loda Massimo, Kufe Donald (Aug. 2003). "Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein". Mol. Cancer Res. (United States) 1 (10): 765-75. ISSN 1541-7786. PMID 12939402. 
  6. ^ Kinch, M S; Clark G J, Der C J, Burridge K (Jul. 1995). "Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia". J. Cell Biol. (UNITED STATES) 130 (2): 461-71. ISSN 0021-9525. PMID 7542250. 
  7. ^ a b Shibata, T; Gotoh M, Ochiai A, Hirohashi S (Aug. 1994). "Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation". Biochem. Biophys. Res. Commun. (UNITED STATES) 203 (1): 519-22. doi:10.1006/bbrc.1994.2213. ISSN 0006-291X. PMID 8074697. 
  8. ^ Hinck, L; Näthke I S, Papkoff J, Nelson W J (Jun. 1994). "Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly". J. Cell Biol. (UNITED STATES) 125 (6): 1327-40. ISSN 0021-9525. PMID 8207061. 
  9. ^ Knudsen, K A; Wheelock M J (Aug. 1992). "Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin". J. Cell Biol. (UNITED STATES) 118 (3): 671-9. ISSN 0021-9525. PMID 1639850. 
  10. ^ Straub, Beate K; Boda Judit, Kuhn Caecilia, Schnoelzer Martina, Korf Ulrike, Kempf Tore, Spring Herbert, Hatzfeld Mechthild, Franke Werner W (Dec. 2003). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell. Sci. (England) 116 (Pt 24): 4985-95. doi:10.1242/jcs.00815. ISSN 0021-9533. PMID 14625392. 
  11. ^ a b Sacco, P A; McGranahan T M, Wheelock M J, Johnson K R (Aug. 1995). "Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin". J. Biol. Chem. (UNITED STATES) 270 (34): 20201-6. ISSN 0021-9258. PMID 7650039. 
  12. ^ Klingelhöfer, J; Troyanovsky R B, Laur O Y, Troyanovsky S (Aug. 2000). "Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions". J. Cell. Sci. (ENGLAND) 113 ( Pt 16): 2829-36. ISSN 0021-9533. PMID 10910767. 
  13. ^ Roe, S; Koslov E R, Rimm D L (Jun. 1998). "A mutation in alpha-catenin disrupts adhesion in clone A cells without perturbing its actin and beta-catenin binding activity". Cell Adhes. Commun. (SWITZERLAND) 5 (4): 283-96. ISSN 1061-5385. PMID 9762469. 
  14. ^ Obama, H; Ozawa M (Apr. 1997). "Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin)". J. Biol. Chem. (UNITED STATES) 272 (17): 11017-20. ISSN 0021-9258. PMID 9110993. 
  15. ^ Lewalle, J M; Bajou K, Desreux J, Mareel M, Dejana E, Noël A, Foidart J M (Dec. 1997). "Alteration of interendothelial adherens junctions following tumor cell-endothelial cell interaction in vitro". Exp. Cell Res. (UNITED STATES) 237 (2): 347-56. doi:10.1006/excr.1997.3799. ISSN 0014-4827. PMID 9434630. 
  16. ^ Shasby, D Michael; Ries Dana R, Shasby Sandra S, Winter Michael C (Jun. 2002). "Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin". Am. J. Physiol. Lung Cell Mol. Physiol. (United States) 282 (6): L1330-8. doi:10.1152/ajplung.00329.2001. ISSN 1040-0605. PMID 12003790. 
  17. ^ Bannon, L J; Cabrera B L, Stack M S, Green K J (Nov. 2001). "Isoform-specific differences in the size of desmosomal cadherin/catenin complexes". J. Invest. Dermatol. (United States) 117 (5): 1302-6. doi:10.1046/j.1523-1747.2001.01512.x. ISSN 0022-202X. PMID 11710948. 
  18. ^ Wahl JK3rd; Nieset J E, Sacco-Bubulya P A, Sadler T M, Johnson K R, Wheelock M J (May. 2000). "The amino- and carboxyl-terminal tails of (beta)-catenin reduce its affinity for desmoglein 2". J. Cell. Sci. (ENGLAND) 113 ( Pt 10): 1737-45. ISSN 0021-9533. PMID 10769205. 
  19. ^ Ozawa, M; Terada H, Pedraza C (Nov. 1995). "The fourth armadillo repeat of plakoglobin (gamma-catenin) is required for its high affinity binding to the cytoplasmic domains of E-cadherin and desmosomal cadherin Dsg2, and the tumor suppressor APC protein". J. Biochem. (JAPAN) 118 (5): 1077-82. ISSN 0021-924X. PMID 8749329. 
  20. ^ Kowalczyk, A P; Navarro P, Dejana E, Bornslaeger E A, Green K J, Kopp D S, Borgwardt J E (Oct. 1998). "VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: a pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions". J. Cell. Sci. (ENGLAND) 111 ( Pt 20): 3045-57. ISSN 0021-9533. PMID 9739078. 
  21. ^ Kowalczyk, A P; Bornslaeger E A, Borgwardt J E, Palka H L, Dhaliwal A S, Corcoran C M, Denning M F, Green K J (Nov. 1997). "The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes". J. Cell Biol. (UNITED STATES) 139 (3): 773-84. ISSN 0021-9525. PMID 9348293. 
  22. ^ Daniel, J M; Reynolds A B (Sep. 1995). "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin". Mol. Cell. Biol. (UNITED STATES) 15 (9): 4819-24. ISSN 0270-7306. PMID 7651399. 
  23. ^ Fuchs, M; Müller T, Lerch M M, Ullrich A (Jul. 1996). "Association of human protein-tyrosine phosphatase kappa with members of the armadillo family". J. Biol. Chem. (UNITED STATES) 271 (28): 16712-9. ISSN 0021-9258. PMID 8663237. 
  24. ^ Chen, Xinyu; Bonne Stefan, Hatzfeld Mechthild, van Roy Frans, Green Kathleen J (Mar. 2002). "Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling". J. Biol. Chem. (United States) 277 (12): 10512-22. doi:10.1074/jbc.M108765200. ISSN 0021-9258. PMID 11790773. 

Further reading

  • Cowin P, Kapprell HP, Franke WW, Tamkun J, Hynes RO (September 1986). "Plakoglobin: a protein common to different kinds of intercellular adhering junctions". Cell 46 (7): 1063–73. PMID 3530498. http://linkinghub.elsevier.com/retrieve/pii/0092-8674(86)90706-3. 
  • Franke WW, Goldschmidt MD, Zimbelmann R, Mueller HM, Schiller DL, Cowin P (June 1989). "Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein". Proc. Natl. Acad. Sci. U.S.A. 86 (11): 4027–31. PMID 2726765. 
  • Mathur M, Goodwin L, Cowin P (May 1994). "Interactions of the cytoplasmic domain of the desmosomal cadherin Dsg1 with plakoglobin". J. Biol. Chem. 269 (19): 14075–80. PMID 8188687. 
  • Beavon IR (2000). "The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation.". Eur. J. Cancer 36 (13 Spec No): 1607–20. doi:10.1016/S0959-8049(00)00158-1. PMID 10959047. 
  • Wilson PD (2001). "Polycystin: new aspects of structure, function, and regulation.". J. Am. Soc. Nephrol. 12 (4): 834–45. PMID 11274246. 
  • Protonotarios NI, Tsatsopoulou AA, Gatzoulis KA (2002). "Arrhythmogenic right ventricular cardiomyopathy caused by a deletion in plakoglobin (Naxos disease).". Cardiac electrophysiology review 6 (1-2): 72–80. doi:10.1023/A:1017943323473. PMID 11984022. 
  • Knudsen KA, Wheelock MJ (1992). "Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin.". J. Cell Biol. 118 (3): 671–9. doi:10.1083/jcb.118.3.671. PMID 1639850. 
  • Arnemann J, Spurr NK, Wheeler GN, et al. (1991). "Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP).". Genomics 10 (3): 640–5. doi:10.1016/0888-7543(91)90446-L. PMID 1889810. 
  • Kinch MS, Clark GJ, Der CJ, Burridge K (1995). "Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia.". J. Cell Biol. 130 (2): 461–71. doi:10.1083/jcb.130.2.461. PMID 7542250. 
  • Aberle H, Bierkamp C, Torchard D, et al. (1995). "The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers.". Proc. Natl. Acad. Sci. U.S.A. 92 (14): 6384–8. doi:10.1073/pnas.92.14.6384. PMID 7604000. 
  • Sacco PA, McGranahan TM, Wheelock MJ, Johnson KR (1995). "Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin.". J. Biol. Chem. 270 (34): 20201–6. doi:10.1074/jbc.270.34.20201. PMID 7650039. 
  • Daniel JM, Reynolds AB (1995). "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin.". Mol. Cell. Biol. 15 (9): 4819–24. PMID 7651399. 
  • Kanai Y, Ochiai A, Shibata T, et al. (1995). "c-erbB-2 gene product directly associates with beta-catenin and plakoglobin.". Biochem. Biophys. Res. Commun. 208 (3): 1067–72. doi:10.1006/bbrc.1995.1443. PMID 7702605. 
  • Roh JY, Stanley JR (1995). "Plakoglobin binding by human Dsg3 (pemphigus vulgaris antigen) in keratinocytes requires the cadherin-like intracytoplasmic segment.". J. Invest. Dermatol. 104 (5): 720–4. doi:10.1111/1523-1747.ep12606963. PMID 7738346. 
  • Shibamoto S, Hayakawa M, Takeuchi K, et al. (1995). "Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes.". J. Cell Biol. 128 (5): 949–57. doi:10.1083/jcb.128.5.949. PMID 7876318. 
  • Rubinfeld B, Souza B, Albert I, et al. (1995). "The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin.". J. Biol. Chem. 270 (10): 5549–55. doi:10.1074/jbc.270.10.5549. PMID 7890674. 
  • Troyanovsky SM, Troyanovsky RB, Eshkind LG, et al. (1994). "Identification of amino acid sequence motifs in desmocollin, a desmosomal glycoprotein, that are required for plakoglobin binding and plaque formation.". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 10790–4. doi:10.1073/pnas.91.23.10790. PMID 7971964. 
  • Shibata T, Gotoh M, Ochiai A, Hirohashi S (1994). "Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation.". Biochem. Biophys. Res. Commun. 203 (1): 519–22. doi:10.1006/bbrc.1994.2213. PMID 8074697. 
  • Hinck L, Näthke IS, Papkoff J, Nelson WJ (1994). "Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly.". J. Cell Biol. 125 (6): 1327–40. doi:10.1083/jcb.125.6.1327. PMID 8207061. 
  • Arnemann J, Sullivan KH, Magee AI, et al. (1993). "Stratification-related expression of isoforms of the desmosomal cadherins in human epidermis.". J. Cell. Sci. 104 ( Pt 3): 741–50. PMID 8314871. 
  • Ozawa M, Nuruki K, Toyoyama H, Ohi Y (1996). "Cloning of an alternative form of plakoglobin (gamma-catenin) lacking the fourth armadillo repeat.". J. Biochem. 118 (4): 836–40. PMID 8576101. 
  • Fuchs M, Müller T, Lerch MM, Ullrich A (1996). "Association of human protein-tyrosine phosphatase kappa with members of the armadillo family.". J. Biol. Chem. 271 (28): 16712–9. doi:10.1074/jbc.271.28.16712. PMID 8663237. 


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v • d • e
Proteins of the cytoskeleton
Human

Actins (A1, A2, B, G1, G2)

Myosins (1A, 1B, 1C, MYH1, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYH10, MYH11, MYH13, MYH14, MYH15, MYH16)

Tropomodulin (1, 2, 3, 4) · Troponin (T 1 2 3, C 1 2, I 1 2 3) · Tropomyosin (1, 2, 3, 4)

other related: Actinin (1, 2, 3, 4) · Arp2/3 complex · actin depolymerizing factors (Cofilin (1, 2) · Destrin) · Gelsolin · Profilin (1, 2)
Other
type 1 and 2 (Cytokeratin, type I, type II) · type 3 (Desmin, GFAP, Peripherin, Vimentin) · type 4 (Internexin, Nestin, Neurofilament, Synemin, Syncoilin) · type 5 (Lamin A, B)
Alpha catenin · Beta catenin · Plakoglobin (gamma catenin) · Delta catenin
Other
Nonhuman
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Histology: epithelial tissue
Types
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Apical

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