n
The primary soft tissue plasma cell tumors of the oral, pharyngeal, and nasal mucous membranes. The lesion consists of typical and atypical plasma cells, and its behavior is unpredictable.
Plasmacytoma
| Dental Dictionary: plasmacytoma |
(plaz′məsītō′mə)
n
n
| 5min Related Video: Plasmacytoma |
| Medical Dictionary: plas·ma·cy·to·ma |
(plăz'mə-sī-tō'mə)
n., -mas or plas·ma·cy·to·ma·ta (-mə-tə).
n., -mas or plas·ma·cy·to·ma·ta (-mə-tə).
A discrete, usually solitary mass of neoplastic plasma cells in bone or in one of various extramedullary sites.
| Veterinary Dictionary: plasmacytoma |
Any focal neoplasm of plasmacytes, including those of multiple myeloma (immunoblastic sarcoma). Isolated plasmacytomas may occur outside the bone marrow (extramedullary plasmacytomas), affecting such tissues as the nasal, oral, pharyngeal and gastrointestinal mucosa and other viscera; called also plasma cell tumor.
| WordNet: plasmacytoma |
Note: click on a word meaning below to see its connections and related words.
The noun has one meaning:
Meaning #1:
neoplasm of plasma cells (usually in bone marrow)
| Wikipedia: Plasmacytoma |
| Plasmacytoma | |
|---|---|
| Classification and external resources | |
 Micrograph of a plasmacytoma. H&E stain. |
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| ICD-10 | C90.2 |
| ICD-9 | 238.6 |
| ICD-O: | M9731/3, M9734/3 |
| DiseasesDB | 8628 |
| eMedicine | med/2532 |
| MeSH | D010954 |
Plasmacytoma refers to a malignant plasma cell tumor[1] growing within soft tissue or within the skeleton. The skeletal forms usually have other occult tumors and frequently disseminate to multiple myeloma over the course of 5–10 years. The soft tissue forms most often occur in the upper respiratory tract, rarely disseminate, and are cured by resection. Most but not all cases produce paraproteinemia.
Contents |
Terminology
There can be some ambiguity when using the word.
"Plasmacytoma" is sometimes equated with "plasma cell dyscrasia" or "solitary myeloma".[2]
It is often used as part of the phrase "solitary plasmacytoma".[3][4][5]
It is also used as part of the phrase "extramedullary plasmacytoma ".[6][7] In this context, "extramedullary" means outside of the bone marrow.
Diagnosis
It is diagnosed by immunoglobulin electrophoresis (or Serum protein electrophoresis) and bone marrow biopsy. Immunoglobulin electrophoresis will show a monoclonal M spike, but bone marrow biopsy will fail to find the classical signs of multiple myeloma. After those two determinations are made, search for the primary site in the soft tissue begins.
Gallery
 Micrograph of a plasmacytoma. |
See also
- Cutaneous B-cell lymphoma
- Waldenstrom's macroglobulinemia
- Monoclonal gammopathy of undetermined significance or MGUS
References
- ^ "CRC - Glossary P". http://cll.ucsd.edu/glossaryp.htm. Retrieved 2009-03-02.
- ^ plasmacytoma at Dorland's Medical Dictionary
- ^ Dimopoulos MA, Moulopoulos LA, Maniatis A, Alexanian R (September 2000). "Solitary plasmacytoma of bone and asymptomatic multiple myeloma". Blood 96 (6): 2037–44. PMID 10979944. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=10979944.
- ^ Di Micco P, Di Micco B (March 2005). "Up-date on solitary plasmacytoma and its main differences with multiple myeloma". Exp. Oncol. 27 (1): 7–12. PMID 15812350. http://www.exp-oncology.com.ua/en/archives/21/383.html.
- ^ Dingli D, Kyle RA, Rajkumar SV, et al. (September 2006). "Immunoglobulin free light chains and solitary plasmacytoma of bone". Blood 108 (6): 1979–83. doi:. PMID 16741249. PMC: 1895544. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=16741249.
- ^ Megat Shiraz MA, Jong YH, Primuharsa Putra SH (November 2008). "Extramedullary plasmacytoma in the maxillary sinus". Singapore Med J 49 (11): e310–1. PMID 19037537. http://smj.sma.org.sg/4911/4911cr6.pdf.
- ^ Bink K, Haralambieva E, Kremer M, et al. (April 2008). "Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics". Haematologica 93 (4): 623–6. doi:. PMID 18326524. http://www.haematologica.org/cgi/pmidlookup?view=long&pmid=18326524.
External links
- The Internet Journal of Otorhinolaryngology
- The Doctor's Doctor
- Overview at National Cancer Institute
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 | Dental Dictionary. Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved. Read more |
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| Medical Dictionary. The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Read more |
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| Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more |
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| WordNet. WordNet 1.7.1 Copyright © 2001 by Princeton University. All rights reserved. Read more |
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