PML
abbr. for promyelocytic leukemia protein; a protein that occurs free in nucleoplasm and in association with other proteins in nuclear bodies. The gene at 15q21 encodes a protein that contains a RING finger and a coiled-coil domain, and resembles COP1 in structure, cell distribution, and dynamics. A translocation between the PML gene and the RARĪ± gene produces the fusion protein PML-RARĪ± and disrupts the nuclear bodies. Cytoplasmic aggregates of PML occur in virally infected, neoplastic, or inflamed tissue.
| PMF, PMA, PLZF | |
| PMN, PMR, PMS |
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PML
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Oxford Dictionary of Biochemistry
Oxford University Press. Oxford Dictionary of Biochemistry and Molecular Biology © 1997, 2000, 2006 All rights reserved.
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