PMPCB
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| Peptidase (mitochondrial processing) beta | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | PMPCB; Beta-MPP; MPP11; MPPB; MPPP52; P-52 | ||||||||||||
| External IDs | OMIM: 603131 MGI: 1920328 HomoloGene: 3160 GeneCards: PMPCB Gene | ||||||||||||
| EC number | 3.4.24.64 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9512 | 73078 | |||||||||||
| Ensembl | ENSG00000105819 | ENSMUSG00000029017 | |||||||||||
| UniProt | O75439 | Q3TET5 | |||||||||||
| RefSeq (mRNA) | NM_004279 | NM_028431.2 | |||||||||||
| RefSeq (protein) | NP_004270 | NP_082707.1 | |||||||||||
| Location (UCSC) | Chr 7: 102.94 – 102.97 Mb |
Chr 5: 21.24 – 21.26 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Mitochondrial-processing peptidase subunit beta is an enzyme that in humans is encoded by the PMPCB gene.[1][2]
This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex.[2]
Interactions
PMPCB has been shown to interact with Frataxin.[3]
References
- ^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20949.
- ^ a b "Entrez Gene: PMPCB peptidase (mitochondrial processing) beta". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9512.
- ^ Koutnikova, H; Campuzano V, Koenig M (Sep. 1998). "Maturation of wild-type and mutated frataxin by the mitochondrial processing peptidase". Hum. Mol. Genet. (ENGLAND) 7 (9): 1485–9. doi:10.1093/hmg/7.9.1485. ISSN 0964-6906. PMID 9700204.
Further reading
- Koutnikova H, Campuzano V, Koenig M (1998). "Maturation of wild-type and mutated frataxin by the mitochondrial processing peptidase.". Hum. Mol. Genet. 7 (9): 1485–9. doi:10.1093/hmg/7.9.1485. PMID 9700204.
- Gordon DM, Shi Q, Dancis A, Pain D (1999). "Maturation of frataxin within mammalian and yeast mitochondria: one-step processing by matrix processing peptidase.". Hum. Mol. Genet. 8 (12): 2255–62. doi:10.1093/hmg/8.12.2255. PMID 10545606.
- Nagao Y, Kitada S, Kojima K, et al. (2000). "Glycine-rich region of mitochondrial processing peptidase alpha-subunit is essential for binding and cleavage of the precursor proteins.". J. Biol. Chem. 275 (44): 34552–6. doi:10.1074/jbc.M003110200. PMID 10942759.
- Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310934.
- Schwer B, North BJ, Frye RA, et al. (2002). "The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase.". J. Cell Biol. 158 (4): 647–57. doi:10.1083/jcb.200205057. PMC 2174009. PMID 12186850. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2174009.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515316.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
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