polyglutamine disease
Oxford Dictionary of Biochemistry:
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polyglutamine disease
any disease of humans caused by the expansion of a CAG trinucleotide repeat in a gene. On expression, the region that contains the elongated stretch of glutamine repeats misfolds and forms antiparallel beta strands, with consequent production of nuclear and cytoplasmic inclusions. Examples include Huntington's disease, spinobulbar muscular atrophy, and various forms of spinocerebellar ataxia.
| polyglutamine, polyglucosan, polygenic | |
| polygon, polyhedron, polyhormone |
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polyglutamine disease
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Oxford Dictionary of Biochemistry
Oxford University Press. Oxford Dictionary of Biochemistry and Molecular Biology © 1997, 2000, 2006 All rights reserved.
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