Polymerase (DNA directed), alpha 1

Polymerase (DNA directed), alpha 1, catalytic subunit
PDB rendering based on 1k0p.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1K0P, 1K18, 1N5G
Identifiers
Symbols	POLA1; POLA; p180
External IDs	OMIM: 312040 MGI: 99660 HomoloGene: 6802 ChEMBL: 1828 GeneCards: POLA1 Gene
EC number	2.7.7.7
Gene Ontology Molecular function • nucleotide binding • nucleoside binding • DNA binding • DNA binding • chromatin binding • double-stranded DNA binding • DNA-directed DNA polymerase activity • DNA-directed DNA polymerase activity • DNA primase activity • protein binding • transferase activity • nucleotidyltransferase activity • purine nucleotide binding • pyrimidine nucleotide binding • metal ion binding • protein heterodimerization activity Cellular component • chromatin • nucleus • nuclear envelope • nucleoplasm • nucleoplasm • alpha DNA polymerase:primase complex • alpha DNA polymerase:primase complex • nucleolus • nucleolus • cytoplasm • nuclear matrix • intracellular membrane-bounded organelle Biological process • DNA replication checkpoint • G1/S transition of mitotic cell cycle • regulation of transcription involved in G1/S phase of mitotic cell cycle • S phase of mitotic cell cycle • S phase of mitotic cell cycle • M/G1 transition of mitotic cell cycle • mitotic cell cycle • telomere maintenance via recombination • telomere maintenance • DNA synthesis involved in DNA repair • nucleobase-containing compound metabolic process • DNA replication • DNA replication, synthesis of RNA primer • DNA-dependent DNA replication initiation • DNA-dependent DNA replication initiation • DNA strand elongation involved in DNA replication • DNA strand elongation involved in DNA replication • leading strand elongation • lagging strand elongation • DNA repair • double-strand break repair via nonhomologous end joining • cell proliferation • telomere maintenance via semi-conservative replication • interspecies interaction between organisms Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5422	18968
Ensembl	ENSG00000101868	ENSMUSG00000006678
UniProt	P09884	P33609
RefSeq (mRNA)	NM_016937.3	NM_008892.2
RefSeq (protein)	NP_058633.2	NP_032918.1
Location (UCSC)	Chr X: 24.71 – 25.02 Mb	Chr X: 90.55 – 90.88 Mb
PubMed search	[1]	[2]
This box: view talk edit

DNA polymerase alpha catalytic subunit is an enzyme that in humans is encoded by the POLA1 gene.^[1]

Pol α has limited processivity and lacks 3′ exonuclease activity for proofreading errors. Thus it is not well suited to efficiently and accurately copy long templates (unlike Pol Delta and Epsilon). Instead it plays a more limited role in replication. Pol α is responsible for the initiation of DNA replication at origins and during lagging-strand synthesis of Okazaki fragments.

Interactions

DNA dependent polymerase alpha (Pol α) has been shown to interact with Retinoblastoma protein,^[2] PARP1^[3] and RBMS1.^[4]

References

Further reading

v t e PDB gallery 1k0p: NMR Structures of the Zinc Finger Domain of Human DNA Polymerase-alpha   1k18: Minimized Average NMR Structure of the Zinc Finger Domain of Human DNA Polymerase-alpha   1n5g: NMR Structures of the Zinc Finger Domain of Human DNA Polymerase-alpha

This article on a gene on the X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it. v t e