Polymorphous low-grade adenocarcinoma
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Polymorphous low-grade adenocarcinoma
| Polymorphous low-grade adenocarcinoma | |
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| Classification and external resources | |
 Low magnification micrograph of a polymorphous low-grade adenocarcinoma, showing the typical variation of architectural arrangement. H&E stain. |
Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare,asymptomatic,slow-growing malignant salivary gland tumor.[1] It is most commonly found in the palate.[2]
The name of the tumor derives from the fact that:
- It has a varied microscopic architectural appearance, i.e. it is polymorphous.
- It is non-aggressive when compared to other oral cavity tumors, i.e. it is a low-grade tumor.[1]
- It forms glands, i.e. it is an adenocarcinoma.
Its the second most common melignancy tumor of the salivary glands after Mucoepidermoid Carcinoma, Afftects the minor salivary glands in the area between the hard and the soft palate. Male to female ratio is 3:1, and the average age is 56 years.
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Contents
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Histology
PLGAs consist of a monomorphous cell population that has a varied histologic morphology.
Microscopically, its histology can be confused with an adenoid cystic carcinoma and a pleomorphic adenoma.
Treatment
PLGAs are treated with wide local surgical excision and long-term follow-up.[2] There is a recurrence rate of 14% (Peterson, contemporary of oral and maxillofacial surgery).
Additional images
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Polymorphous low-grade adenocarcinoma. H&E stain.
Additional reading
- Kahn, Michael A. Basic Oral and Maxillofacial Pathology. Volume 1. 2001.
References
- ^ a b Arathi N, Bage AM (2009). "Polymorphous low-grade adenocarcinoma of parotid gland: a rare occurrence". Indian J Pathol Microbiol 52 (1): 103–5. PMID 19136798.
- ^ a b Paleri V, Robinson M, Bradley P (April 2008). "Polymorphous low-grade adenocarcinoma of the head and neck". Curr Opin Otolaryngol Head Neck Surg 16 (2): 163–9. doi:10.1097/MOO.0b013e3282f70441. PMID 18327037.
External links
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