Polythiazide

Polythiazide

Systematic (IUPAC) name
6-chloro-2-methyl-3-{[(2,2,2-trifluoroethyl)thio]methyl}-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a601101
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	346-18-9 Y
ATC code	C03AA05
PubChem	CID 4870
ChemSpider	4704 N
UNII	36780APV5N N
KEGG	D00657 N
ChEMBL	CHEMBL1587 N
Chemical data
Formula	C11H13ClF3N3O4S3
Mol. mass	439.88 g/mol
N(what is this?)  (verify)

Polythiazide is a thiazide diuretic.^[1][2]

References

1. ^ O'Brien, E. T.; MacKinnon, J. (1972). "Propranolol and polythiazide in treatment of hypertension". British heart journal 34 (10): 1042–1044. PMC 458544. PMID 5086971.  edit
2. ^ Monroy, A.; Plata, C.; Hebert, S. C.; Gamba, G. (2000). "Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: A new model for ions and diuretics interaction". American journal of physiology. Renal physiology 279 (1): F161–F169. PMID 10894798.  edit

v d e Symporter inhibitors Sodium chloride thiazide: Bendroflumethiazide  • Chlorothiazide  • Cyclopenthiazide  • Cyclothiazide  • Hydrochlorothiazide  • Hydroflumethiazide  • Methyclothiazide  • Polythiazide  • Trichlormethiazide other: Chlorthalidone  • Metolazone Sodium, potassium, chloride Bumetanide  • Furosemide

v d e Antihypertensives: diuretics (C03) Sulfonamides (and etacrynic acid) CA inhibitors (at PT) Acetazolamide Loop (Na-K-Cl at AL) Furosemide# • Bumetanide • Etacrynic acid • Etozoline • Muzolimine • Piretanide • Tienilic acid • Torasemide Thiazides (Na-Cl at DCT, Calcium-sparing) Hydrochlorothiazide# • Bendroflumethiazide • Hydroflumethiazide • Chlorothiazide • Polythiazide • Trichlormethiazide • Cyclopenthiazide • Methyclothiazide • Cyclothiazide • Mebutizide Thiazide-likes (primarily DCT) Quinethazone • Clopamide • Chlortalidone • Mefruside • Clofenamide • Metolazone • Meticrane • Xipamide • Indapamide • Clorexolone • Fenquizone Potassium-sparing (at CD) ESC blockers Amiloride# • Triamterene • Benzamil Aldosterone antagonists Spironolactone# • Eplerenone • Potassium canrenoate • Canrenone Osmotic diuretics (PT, DL) Mannitol# • Urea Vasopressin receptor antagonists (DCT and CD) vaptans: Conivaptan • Mozavaptan • Satavaptan • Tolvaptan tetracyclines: Demeclocycline Other mercurial diuretic (Mersalyl) • Theobromine • Cicletanine #WHO-EM. ‡Withdrawn from market. Clinical trials: †Phase III. §Never to phase III M: VAS anat(a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot noco/syva/cong/lyvd/tumr, sysi/epon, injr proc, drug(C2s+n/3/4/5/7/8/9)

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