Ponce de León may refer to:
People
- Juan Ponce de León (1474–1521), Spanish conquistador
- Juan Ponce de León II (1524–1591), the first Puerto Rican to assume (temporarily) the governorship of Puerto Rico
- Juan Ponce de León y Loayza, the son of Juan Ponce de León II, and early settler of Ponce, Puerto Rico
- Luis Ponce de León (governor of New Spain) (1460–1521), Spanish governor of New Spain
- Luis Ponce de León (1527–1591), Spanish poet
- Diego de Alvear y Ponce de León (1749–1830), Spanish military commander and politician
- Diego de Vargas (Diego de Vargas Zapata y Luján Ponce de León y Contreras, 1643–1704), Spanish governor of the New Spain territory of Santa Fe de Nuevo México, today the U.S. states of New Mexico and Arizona
- Rodrigo Ponce de León, 4th Duke of Arcos, viceroy of Naples (r. 1646–48)
- Daniel Ponce de León, Mexican boxer
Places
- Ponce de Leon, Florida, a town in the United States
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