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Posaconazole

Brand names: Noxafil®



Posaconazole oral suspension

What is Posaconazole oral suspension?

POSACONAZOLE (Noxafil®) is an antifungal type of antibiotic. It is used to prevent serious fungal infections in patients with a weak immune system.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• heart disease
• liver disease
• kidney disease or on dialysis
• an unusual reaction to posaconazole, voriconazole, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should this medicine be used?

Take this medicine by mouth. Use a specially marked spoon to measure the dose. Ask your pharmacist if you do not have one; household spoons are not accurate. Follow the directions on the prescription label. Take this medicine with a full meal or an oral liquid nutritional supplement; taking it with food makes it more effective. If you can not eat a full meal or tolerate a liquid nutrition supplement, it is important to let your healthcare provider know this. Take your doses at regular intervals. Do not take your medicine more often than directed. Finish the full course prescribed even if you think your condition is better. Do not stop taking except on your prescriber's advice.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What drug(s) may interact with Posaconazole?

Do not take posaconazole with the following medications:
• astemizole (Hismanal®)
• cimetidine (Tagamet®)
• cisapride (Propulsid®)
• dihydroergotamine, ergotamine, or methysergide
• pimozide (Orap®)
• quinidine (Cardioquin®, Quinidex®, Quinaglute®)
• rifabutin (Mycobutin®)
• terfenadine (Seldane®)

Medications that require or may require dosage adjustments when given with posaconazole:
• calcium channel blockers like amlodipine, diltiazem, or verapamil
• cerivastatin (Baycol®)
cyclosporine
• lovastatin (Advicor®, Altocor™, Mevacor®)
phenytoin
• simvastatin (Zocor®)
sirolimus
tacrolimus

Other drugs which may interact with posaconazole include:
• benzodiazepines (e.g., alprazolam, chlordiazepoxide, clonazepam, clorazepate, estazolam, flurazepam, midazolam, prazepam, quazepam, and triazolam)
• red yeast rice
• vinca alkaloids (e.g., vincristine or vinblastine)

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking Posaconazole?

This medicine must be taken with a full meal or liquid nutritional supplement. If you can not eat a full meal or tolerate a liquid nutritional supplement, let your healthcare provider know immediately.

This medicine is used to prevent fungal infections. If you develop severe diarrhea or vomiting while taking this medicine, let your health care provider know immediately. This medicine may also be prescribed to treat fungal infections. If this is the case, tell your prescriber or health care professional if your symptoms do not begin to improve in 1 to 2 weeks. Some fungal infections need many weeks or months of treatment to cure. Take your medicine regularly for as long as your prescriber or health care professional tells you to.

Do not take cimetidine (Tagamet®) with this medicine. Cimetidine is available without a prescription and is available in many products. Contact your healthcare provider for alternatives to cimetidine.

What side effects may I notice from receiving Posaconazole?

Side effects that you should report to your prescriber or health care professional as soon as possible:
• difficulty breathing
• fever
• redness, blistering, peeling or loosening of the skin, including inside the mouth
• severe diarrhea
• skin rash, itching
• swelling of legs
• unusual bruising or bleeding
• vomiting
• yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• back pain
• chills
• constipation
• difficulty sleeping
• dizziness
• headache
• loss of appetite
• muscle pain
• nausea
• stomach pain or upset
• tiredness
• weakness

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Store at 25 degrees C (77 degrees F). DO NOT FREEZE. Throw away any unused medicine after the expiration date.

Last updated: 8/28/2003 4:45:00 PM

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.



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