positional cloning
Oxford Dictionary of Biochemistry:
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positional cloning
a strategy for the identification of a gene of unknown function responsible for a genetic disease. The phenotype is correlated with a chromosomal site, the DNA of that region is cloned and compared with that in normal individuals. If a single gene is involved, it is sequenced, and the protein structure deduced. An example is the discovery of the genetic basis of cystic fibrosis and the identification of the cystic fibrosis transmembrane conductance regulator (CFTR).
| position-specific scoring matrix, position-specific iterated-BLAST, porter | |
| positional information, positional isomer, positive |
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positional cloning
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Oxford Dictionary of Biochemistry
Oxford University Press. Oxford Dictionary of Biochemistry and Molecular Biology © 1997, 2000, 2006 All rights reserved.
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