Positive allosteric modulator
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Positive allosteric modulator
A positive allosteric modulator (PAM) is a drug which increases the activity of a receptor indirectly via activation of an allosteric site on the protein. PAMs are similar to agonists in that they contribute to overall receptor activation, but they are different because they do so in a functionally distinctive way.[1][2]
Main article: Allosteric regulation
See also
References
- ^ J. Monod, J. Wyman, J.P. Changeux. (1965). "On the nature of allosteric transitions:A plausible model". J. Mol. Biol. 12 (May): 88–118.
- ^ "From enzymatic adaptation to allosteric transitions, Nobel Lecture, December 11, 1965". http://130.237.143.81/nobel_prizes/medicine/laureates/1965/monod-lecture.pdf.
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