Potassium channel opener
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Potassium channel opener
A potassium channel opener is a type of drug which facilitates ion transmission through potassium channels.
Some examples include:
- Diazoxide[1] vasodilator used for hypertension, smooth muscle relaxing activity
- Minoxidil[2] vasodilator used for hypertension, also used to treat hair loss
- Nicorandil[3] vasodilator used to treat angina
- Pinacidil[4]
- Retigabine[5][6], an anticonvulsant
- Flupirtine, analgesic with muscle relaxant and anticonvulsant properties
See also
References
- ^ Mizutani S, Prasad SM, Sellitto AD, Schuessler RB, Damiano RJ, Lawton JS (August 2005). "Myocyte volume and function in response to osmotic stress: observations in the presence of an adenosine triphosphate-sensitive potassium channel opener". Circulation 112 (9 Suppl): I219–23. doi:10.1161/CIRCULATIONAHA.104.523746. PMID 16159820. http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=16159820.
- ^ Wang T (February 2003). "The effects of the potassium channel opener minoxidil on renal electrolytes transport in the loop of henle". J. Pharmacol. Exp. Ther. 304 (2): 833–40. doi:10.1124/jpet.102.043380. PMID 12538840. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=12538840.
- ^ Sudo H, Yogo K, Ishizuka N, Otsuka H, Horie S, Saito K (November 2008). "Nicorandil, a potassium channel opener and nitric oxide donor, improves the frequent urination without changing the blood pressure in rats with partial bladder outlet obstruction" ([dead link]). Biol. Pharm. Bull. 31 (11): 2079–82. doi:10.1248/bpb.31.2079. PMID 18981577. http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/31.2079?from=PubMed.
- ^ Stojnic N, Gojkovic-Bukarica L, Peric M, et al. (June 2007). "Potassium channel opener pinacidil induces relaxation of the isolated human radial artery" ([dead link]). J. Pharmacol. Sci. 104 (2): 122–9. doi:10.1254/jphs.FP0061434. PMID 17538231. http://joi.jlc.jst.go.jp/JST.JSTAGE/jphs/FP0061434?from=PubMed.
- ^ Rundfeldt C (October 1997). "The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells". European Journal of Pharmacology 336 (2–3): 243–9. doi:10.1016/S0014-2999(97)01249-1. PMID 9384239. http://linkinghub.elsevier.com/retrieve/pii/S0014-2999(97)01249-1.
- ^ Main MJ, Cryan JE, Dupere JR, Cox B, Clare JJ, Burbidge SA (August 2000). "Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine". Molecular Pharmacology 58 (2): 253–62. PMID 10908292. http://molpharm.aspetjournals.org/cgi/pmidlookup?view=long&pmid=10908292.
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